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题名: Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy, and Mammary Gland Fibroma
作者: Wang, Changsong1;  Sun, Bo1;  Guo, Lei1;  Wang, Xiaoyang1;  Ke, Chaofu2;  Liu, Shanshan1;  Zhao, Wei1;  Luo, Suqi1;  Guo, Zhigang1;  Zhang, Yang1;  Xu, Guowang3;  Li, Enyou1
刊名: SCIENTIFIC REPORTS
发表日期: 2014-06-20
DOI: 10.1038/srep05383
卷: 4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: The association between cancer and volatile organic metabolites in exhaled breaths has attracted increasing attention from researchers. The present study reports on a systematic study of gas profiles of metabolites in human exhaled breath by pattern recognition methods. Exhaled breath was collected from 85 patients with histologically confirmed breast disease (including 39 individuals with infiltrating ductal carcinoma, 25 individuals with cyclomastopathy and from 21 individuals with mammary gland fibroma) and 45 healthy volunteers. Principal component analysis and partial least squares discriminant analysis were used to process the final data. The volatile organic metabolites exhibited significant differences between breast cancer and normal controls, breast cancer and cyclomastopathy, and breast cancer and mammary gland fibroma; 21, 6, and 8 characteristic metabolites played decisive roles in sample classification, respectively (P<0.05). Three volatile organic metabolites in the exhaled air, 2,5,6-trimethyloctane, 1,4-dimethoxy-2,3-butanediol, and cyclohexanone, distinguished breast cancer patients from healthy individuals, mammary gland fibroma patients, and patients with cyclomastopathy (P<0.05). The identified three volatile organic metabolites associated with breast cancer may serve as novel diagnostic biomarkers.
关键词[WOS]: SWEDISH RANDOMIZED-TRIALS ;  LUNG-CANCER ;  EXHALED BREATH ;  MAMMOGRAPHY ;  DIAGNOSIS ;  CELLS ;  US ;  DERIVATIZATION ;  SPECTROMETRY ;  MORTALITY
语种: 英语
WOS记录号: WOS:000337888300008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145746
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Peoples R China
2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China

Recommended Citation:
Wang, Changsong,Sun, Bo,Guo, Lei,et al. Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy, and Mammary Gland Fibroma[J]. SCIENTIFIC REPORTS,2014,4.
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