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题名: Copper-Mediated Intramolecular Oxidative C-H/C-H Cross-Coupling of alpha-Oxo Ketene N,S-Acetals for Indole Synthesis
作者: Huang, Fei1;  Wu, Ping1;  Wang, Liandi1;  Chen, Jiping1;  Sun, Chenglin1;  Yu, Zhengkun1, 2
刊名: JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2014-11-07
DOI: 10.1021/jo5014542
卷: 79, 期:21, 页:10553-10560
收录类别: SCI ;  IC
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
英文摘要: CuCl2-mediated intramolecular C-H/C-H cross-dehydrogenative coupling (CDC) of thioalkyl-substituted a-acetyl or alpha-aroyl ketene N,S-acetals afforded 2-thioalkyl indoles. Tunable C-S bond transformations of the resultant indoles led to highly functionalized N-heterocyclic compounds. A beta-thioalkyl is necessary to activate the N,S-acetal substrate and enable the CDC reaction to occur, and the relevant mechanism studies revealed that the CDC reaction follows a radical pathway.
关键词[WOS]: N-ARYL ENAMINES ;  BOND ACTIVATION ;  CYCLIZATION ;  ANILINES ;  EFFICIENT ;  FUNCTIONALIZATION ;  HETEROCYCLES ;  ANNULATION ;  CATALYSIS ;  OXIDANT
语种: 英语
WOS记录号: WOS:000344638200056
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145747
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

Recommended Citation:
Huang, Fei,Wu, Ping,Wang, Liandi,et al. Copper-Mediated Intramolecular Oxidative C-H/C-H Cross-Coupling of alpha-Oxo Ketene N,S-Acetals for Indole Synthesis[J]. JOURNAL OF ORGANIC CHEMISTRY,2014,79(21):10553-10560.
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