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题名: The mechanism of different sensitivity of meso-substituted and unsubstituted cyanine dyes in rotation-restricted environments for biomedical imaging applications
作者: Cao, Jianfang1, 2;  Hu, Chong1;  Sun, Wen1;  Xu, Qunli1;  Fan, Jiangli1;  Song, Fengling1;  Sun, Shiguo1;  Peng, Xiaojun1
刊名: RSC ADVANCES
发表日期: 2014
DOI: 10.1039/c3ra46612d
卷: 4, 期:26, 页:13385-13394
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: A series of cyanine dyes have been excellent environment-sensitive fluorescent probes in live cells as well as in living tissue imaging due to their low quantum yields in solution but also their large fluorescence enhancements in microenvironments. In this paper, a new mechanism of different environmental sensitivity of meso-substituted and unsubstituted cyanine dyes in rotation-restricted environments (DNA or viscosity) for biomedical imaging applications is proposed on the basis of experimental observations and quantum-chemically calculated potential energy curves for twisting around the various C-C bonds in the polymethine chain. Computational studies on these dyes reveal substituents on the bridge decrease the energy barriers for rotations around different chemical bonds, which play a major role in reducing fluorescence quantum yield in a free state and providing a high environmental sensitivity for the meso-substituted cyanine dyes. The energy barriers and energy gaps to the rotations of C-C bonds strongly depend on the choice of substituents in the meso-position of the polymethine chain. The results might provide a foundation for the interpretation of the behavior of the dyes and are useful for the future design of new cyanine fluorophores.
关键词[WOS]: FLUORESCENT-PROBES ;  POLYMETHINE CHAIN ;  FLUOROGENIC DYES ;  LIVING CELLS ;  VISCOSITY ;  FLUOROPHORES ;  SENSOR ;  DNA ;  PHOTOPROCESSES ;  CONFORMATIONS
语种: 英语
WOS记录号: WOS:000333082700022
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145749
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Peoples R China

Recommended Citation:
Cao, Jianfang,Hu, Chong,Sun, Wen,et al. The mechanism of different sensitivity of meso-substituted and unsubstituted cyanine dyes in rotation-restricted environments for biomedical imaging applications[J]. RSC ADVANCES,2014,4(26):13385-13394.
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