DICP OpenIR
The mechanism of different sensitivity of meso-substituted and unsubstituted cyanine dyes in rotation-restricted environments for biomedical imaging applications
Cao, Jianfang1,2; Hu, Chong1; Sun, Wen1; Xu, Qunli1; Fan, Jiangli1; Song, Fengling1; Sun, Shiguo1; Peng, Xiaojun1
Source PublicationRSC ADVANCES
2014
DOI10.1039/c3ra46612d
Volume4Issue:26Pages:13385-13394
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordFLUORESCENT-PROBES ; POLYMETHINE CHAIN ; FLUOROGENIC DYES ; LIVING CELLS ; VISCOSITY ; FLUOROPHORES ; SENSOR ; DNA ; PHOTOPROCESSES ; CONFORMATIONS
AbstractA series of cyanine dyes have been excellent environment-sensitive fluorescent probes in live cells as well as in living tissue imaging due to their low quantum yields in solution but also their large fluorescence enhancements in microenvironments. In this paper, a new mechanism of different environmental sensitivity of meso-substituted and unsubstituted cyanine dyes in rotation-restricted environments (DNA or viscosity) for biomedical imaging applications is proposed on the basis of experimental observations and quantum-chemically calculated potential energy curves for twisting around the various C-C bonds in the polymethine chain. Computational studies on these dyes reveal substituents on the bridge decrease the energy barriers for rotations around different chemical bonds, which play a major role in reducing fluorescence quantum yield in a free state and providing a high environmental sensitivity for the meso-substituted cyanine dyes. The energy barriers and energy gaps to the rotations of C-C bonds strongly depend on the choice of substituents in the meso-position of the polymethine chain. The results might provide a foundation for the interpretation of the behavior of the dyes and are useful for the future design of new cyanine fluorophores.
Language英语
WOS IDWOS:000333082700022
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/145749
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Cao, Jianfang,Hu, Chong,Sun, Wen,et al. The mechanism of different sensitivity of meso-substituted and unsubstituted cyanine dyes in rotation-restricted environments for biomedical imaging applications[J]. RSC ADVANCES,2014,4(26):13385-13394.
APA Cao, Jianfang.,Hu, Chong.,Sun, Wen.,Xu, Qunli.,Fan, Jiangli.,...&Peng, Xiaojun.(2014).The mechanism of different sensitivity of meso-substituted and unsubstituted cyanine dyes in rotation-restricted environments for biomedical imaging applications.RSC ADVANCES,4(26),13385-13394.
MLA Cao, Jianfang,et al."The mechanism of different sensitivity of meso-substituted and unsubstituted cyanine dyes in rotation-restricted environments for biomedical imaging applications".RSC ADVANCES 4.26(2014):13385-13394.
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