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题名: Imidazolium-based iodoacetamide functional tags: design, synthesis, and property study for cysteinylpeptide analysis by mass spectrometry
作者: Qiao, Xiaoqiang1, 2;  Wang, Rui1, 2, 3;  Li, Guangyue4;  Yan, Hongyuan1, 2;  Zhou, Yuan3;  Zhang, Lihua3;  Zhang, Yukui3
刊名: ANALYST
发表日期: 2014
DOI: 10.1039/c3an01907a
卷: 139, 期:4, 页:705-708
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: New types of imidazolium-based iodoacetamide tags were designed, synthesized and further exploited for cysteinyl-peptide analysis with superior labeling efficiency, high stability, improved ionization efficiency, and increased charge states bymass spectrometry. For the first time, the effects of these kinds of tags on the mass spectrometry performance of the derivatized peptides were investigated, which is of great importance to help us design more efficient tags for the analysis of peptides or proteins, especially for those with low abundance.
关键词[WOS]: ELECTRON-TRANSFER DISSOCIATION ;  CARBOXY GROUP DERIVATIZATION ;  QUATERNARY AMMONIUM TAG ;  AMINO-ACIDS ;  PEPTIDES ;  MATRIX ;  IONIZATION ;  REAGENTS ;  PHOSPHOPEPTIDES ;  QUANTITATION
语种: 英语
WOS记录号: WOS:000330042500002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145779
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Hebei Univ, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China
2.Hebei Univ, Coll Pharmaceut Sci, Baoding 071002, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
4.Hebei United Univ, Coll Chem Engn, Tangshan 063009, Peoples R China

Recommended Citation:
Qiao, Xiaoqiang,Wang, Rui,Li, Guangyue,et al. Imidazolium-based iodoacetamide functional tags: design, synthesis, and property study for cysteinylpeptide analysis by mass spectrometry[J]. ANALYST,2014,139(4):705-708.
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