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题名: Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7
作者: Ma, Hai-Ying1;  Sun, Dong-Xue2;  Cao, Yun-Feng3, 4;  Ai, Chun-Zhi4;  Qu, Yan-Qing5;  Hu, Cui-Min4, 7;  Jiang, Changtao6;  Dong, Pei-Pei8;  Sun, Xiao-Yu4;  Hong, Mo4;  Tanaka, Naoki6;  Gonzalez, Frank J.6;  Ma, Xiao-Chi3, 4, 8, 9;  Fang, Zhong-Ze3, 4, 6
关键词: Andrographolide derivatives ;  Herb-drug interaction (HDI) ;  UDP-glucuronosyltransferases (UGTs) ;  Adverse effects
刊名: TOXICOLOGY AND APPLIED PHARMACOLOGY
发表日期: 2014-05-15
DOI: 10.1016/j.taap.2014.02.021
卷: 277, 期:1, 页:86-94
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ;  Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ;  Toxicology
英文摘要: Herb-drug interaction strongly limits the clinical application of herbs and drugs, and the inhibition of herbal components towards important drug-metabolizing enzymes (DMEs) has been regarded as one of the most important reasons. The present study aims to investigate the inhibition potential of andrographolide derivatives towards one of the most important phase II DMEs UDP-glucuronosyltransferases (UGTs). Recombinant UGT isoforms (except UGT1A4)-catalyzed 4-methylumbelliferone (4-MU) glucuronidation reaction and UGT1A4catalyzed trifluoperazine ( IFP) glucuronidation were employed to firstly screen the andrographolide derivatives' inhibition potential. High specific inhibition of andrographolide derivatives towards UGT2B7 was observed. The inhibition type and parameters (KO were determined for the compounds exhibiting strong inhibition capability towards UGT2B7, and human liver microsome (HLMs)-catalyzed zidovudine (AZT) glucuronidation probe reaction was used to furtherly confirm the inhibition behavior. In combination of inhibition parameters (KO and in vivo concentration of andrographolide and dehydroandrographolide, the potential in vivo inhibition magnitude was predicted. Additionally, both the in vitro inhibition data and computational modeling results provide important information for the modification of andrographolide derivatives as selective inhibitors of UGT2B7. Taken together, data obtained from the present study indicated the potential herb-drug interaction between Andrographis paniculata and the drugs mainly undergoing UGT2B7-catalyzed metabolic elimination, and the andrographolide derivatives as potential candidates for the selective inhibitors of UGT2B7. (C) 2014 Elsevier Inc. All rights reserved.
关键词[WOS]: ZIDOVUDINE GLUCURONIDATION ;  PANICULATA EXTRACT ;  IN-VITRO ;  ACID ;  4-METHYLUMBELLIFERONE ;  PHARMACOKINETICS ;  SELECTIVITY ;  1-NAPHTHOL ;  BINDING ;  SITES
语种: 英语
WOS记录号: WOS:000335095200010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145787
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.China Med Univ, Affiliated Hosp 4, Shenyang 110032, Peoples R China
2.Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Shenyang 110016, Peoples R China
3.Liaoning Med Univ, Affiliated Hosp 1, Jinzhou 121001, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Joint Ctr Translat Med, Dalian 116023, Peoples R China
5.Yantaishan Hosp, Yantai, Shandong, Peoples R China
6.NCI, Lab Metab, Ctr Canc Res, Bethesda, MD 20892 USA
7.Georgetown Univ, Med Ctr, Dept Microbiol & Immunol, Washington, DC 20057 USA
8.Dalian Med Univ, Acad Integrat Med, Dalian 116044, Peoples R China
9.Med Univ, Coll Pharm, Pharmacokinet & Drug Transport Key Lab, Dalian, Peoples R China

Recommended Citation:
Ma, Hai-Ying,Sun, Dong-Xue,Cao, Yun-Feng,et al. Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2014,277(1):86-94.
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