DICP OpenIR
Novel chiral stationary phases based on peptoid combining a quinine/quinidine moiety through a C9-position carbamate group
Wu, Haibo1; Wang, Dongqiang1; Song, Guangjun1; Ke, Yanxiong1; Liang, Xinmiao1,2
KeywordChiral Stationary Phases Cinchona Alkaloid Enantiomer Separation Enantiorecognition Peptoids
Source PublicationJOURNAL OF SEPARATION SCIENCE
2014-04-01
DOI10.1002/jssc.201301346
Volume37Issue:8Pages:934-943
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordCINCHONA ALKALOIDS ; ANION-EXCHANGERS ; AMINO-ACIDS ; LIQUID-CHROMATOGRAPHY ; QUININE ; ENANTIOSELECTIVITY ; SEPARATIONS ; DERIVATIVES ; RESOLUTION ; RECOGNITION
AbstractBy connecting a quinine or quinidine moiety to the peptoid chain through the C9-position carbamate group, we synthesized two new chiral selectors. After immobilizing them onto 3-mercaptopropyl-modified silica gel, two novel chiral stationary phases were prepared. With neutral, acid, and basic chiral compounds as analytes, we evaluated these two stationary phases and compared their chromatographic performance with chiral columns based on quinine tert-butyl carbamate and the previous peptoid. From the resolution of neutral and basic analytes under normal-phase mode, it was found that the new stationary phases exhibited much better enantioselectivity than the quinine tert-butyl carbamate column; the peptoid moiety played an important role in enantiorecognition, which controlled the elution orders of enantiomers; the assisting role of the cinchona alkaloid moieties was observed in some separations. Under acid polar organic phase mode, it was proved that cinchona alkaloid moieties introduced excellent enantiorecognitions for chiral acid compounds; in some separations, the peptoid moiety affected enantioseparations as well. Overall, chiral moieties with specific enantioselectivity were demonstrated to improve the performance of peptoid chiral stationary phase efficiently.
Language英语
WOS IDWOS:000334059900006
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/145868
Collection中国科学院大连化学物理研究所
Affiliation1.E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Wu, Haibo,Wang, Dongqiang,Song, Guangjun,et al. Novel chiral stationary phases based on peptoid combining a quinine/quinidine moiety through a C9-position carbamate group[J]. JOURNAL OF SEPARATION SCIENCE,2014,37(8):934-943.
APA Wu, Haibo,Wang, Dongqiang,Song, Guangjun,Ke, Yanxiong,&Liang, Xinmiao.(2014).Novel chiral stationary phases based on peptoid combining a quinine/quinidine moiety through a C9-position carbamate group.JOURNAL OF SEPARATION SCIENCE,37(8),934-943.
MLA Wu, Haibo,et al."Novel chiral stationary phases based on peptoid combining a quinine/quinidine moiety through a C9-position carbamate group".JOURNAL OF SEPARATION SCIENCE 37.8(2014):934-943.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wu, Haibo]'s Articles
[Wang, Dongqiang]'s Articles
[Song, Guangjun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wu, Haibo]'s Articles
[Wang, Dongqiang]'s Articles
[Song, Guangjun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wu, Haibo]'s Articles
[Wang, Dongqiang]'s Articles
[Song, Guangjun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.