DICP OpenIR
The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase
Jiang, Li-Peng1; Zhao, Jin2; Cao, Yun-Feng3; Hong, Mo4,5,6,7; Sun, Dong-Xue2; Sun, Xiao-Yu4,5,6,7; Yin, Jun2; Zhu, Zhi-Tu1; Fang, Zhong-Ze8
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2014
DOI10.1155/2014/594354
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]GLUCURONIDATION ; ANDROSTERONE ; RECEPTOR ; UGT
英文摘要Themechanism of shengmai injection-(SMI-) related drug-drug interaction remains unclear. Evaluation of the inhibition potential of SMI's ingredients towards UDP-glucuronosyltransferases (UGTs) activity will provide a new insight to understand SMI-related drug-drug interaction. In vitro incubation system to model UGT reaction was used. Recombinant UGT isoforms-catalyzed 4-methylumbelliferone (4-MU) glucuronidation and UGT1A4-catalyzed trifluoperazine (TFP) glucuronidation reactions were employed to phenotype the inhibition profile of maidong's components towards the activity of UGT isoforms. Different inhibition potential of maidong's components towards various UGT isoforms was observed. Based on the inhibition kinetic investigation results, ophiopogonin D (OD) noncompetitively inhibited UGT1A6 and competitively inhibited UGT1A8, ophiopogonin D ' (OD ') noncompetitively inhibited UGT1A6 and UGT1A10, and ruscorectal (RU) exhibited competitive inhibition towards UGT1A4. The inhibition kinetic parameters were calculated to be 20.6, 40.1, 5.3, 9.0, and 0.02 mu M, respectively. In combination with our previous results obtained for the inhibition of UGT isoforms by ginsenosides and wuweizi components, the important SMI ingredients exhibiting strong inhibition towards UGT isoforms were highlighted. All the results obtained in the present study provide a new insight to understand SMI-related drug-drug interaction.
语种英语
WOS记录号WOS:000344665900001
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/145870
专题中国科学院大连化学物理研究所
作者单位1.Liaoning Med Univ, Affiliated Hosp 1, Jinzhou 121001, Liaoning, Peoples R China
2.Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Shenyang 110016, Peoples R China
3.Shanghai Inst Planned Parenthood Res, Key Lab Contracept & Devices Res NPFPC, Shanghai Engineer & Technol Res Ctr Reprod Hlth D, Shanghai 200032, Peoples R China
4.Chinese Acad Sci, Joint Ctr Translat Med, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
5.Liaoning Med Univ, Affiliated Hosp 1, Dalian 116023, Peoples R China
6.Chinese Acad Sci, Dalian Inst Chem Phys, Joint Ctr Translat Med, Dalian 116001, Peoples R China
7.Dalian Univ, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China
8.Tianjin Med Univ, Dept Toxicol, Sch Publ Hlth, Tianjin 300070, Peoples R China
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GB/T 7714
Jiang, Li-Peng,Zhao, Jin,Cao, Yun-Feng,et al. The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014.
APA Jiang, Li-Peng.,Zhao, Jin.,Cao, Yun-Feng.,Hong, Mo.,Sun, Dong-Xue.,...&Fang, Zhong-Ze.(2014).The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Jiang, Li-Peng,et al."The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014).
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