中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Facile synthesis of functional gadolinium-doped CdTe quantum dots for tumor-targeted fluorescence and magnetic resonance dual-modality imaging
作者: Zhang, Fei1, 2;  Sun, Ting-Ting1, 2;  Zhang, Yan3, 4;  Li, Qiong5, 6;  Chai, Chao5, 6;  Lu, Li5, 6;  Shen, Wen5, 6;  Yang, Jun3, 4;  He, Xi-Wen1, 2;  Zhang, Yu-Kui1, 2, 7;  Li, Wen-You1, 2
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2014
DOI: 10.1039/c4tb00920g
卷: 2, 期:41, 页:7201-7209
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
英文摘要: Magnetic quantum dots (MQDs) are an important class of agents for fluorescence (FL)/magnetic resonance (MR) dual-modal imaging due to their excellent optical and magnetic properties. However, functional MQDs prepared by a simple room-temperature route as FL/MR dual-modal imaging probes are lacking. Herein, we report the fabrication of Gd-doped CdTe quantum dots (Gd:CdTe QDs) as an agent for FL/MR dual-modality imaging. The as-designed QDs with an ultrasmall particle size are synthesized by a facile one-pot aqueous synthesis approach at room temperature. They emit strong fluorescence at 640 nm with a quantum yield of 37% in water, and they have a high longitudinal relaxation rate (r(1)) value of 3.27 mM(-1) s(-1). With the further conjugation of folic acid, the Gd:CdTe QDs can successfully label live HepG2 cells for targeted cellular imaging and present no evidence of cellular toxicity up to the concentration of 0.5 mg mL(-1). They have been employed as a suitable contrast agent successfully for tumor-targeted FL/MR dual-modal imaging in a mouse model.
关键词[WOS]: RAY COMPUTED-TOMOGRAPHY ;  IN-VIVO ;  SEMICONDUCTOR NANOCRYSTALS ;  GOLD NANOCLUSTERS ;  CONTRAST AGENTS ;  NANOPARTICLES ;  NANOPROBES ;  CANCER ;  PROBES ;  PHOTOLUMINESCENCE
语种: 英语
WOS记录号: WOS:000342763700014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145886
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Nankai Univ, Coll Chem, Collaborat Innovat Ctr Chem Sci & Engn, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Nankai Univ, Coll Chem, Res Ctr Analyt Sci, Tianjin 300071, Peoples R China
3.Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
4.Nankai Univ, Coll Life Sci, Key Lab Bioact Mat, Minist Educ, Tianjin 300071, Peoples R China
5.Tianjin Med Univ, Tianjin First Cent Hosp, Cent Clin Coll, Tianjin 300192, Peoples R China
6.Tianjin First Cent Hosp, Dept Radiol, Tianjin 300192, Peoples R China
7.Chinese Acad Sci, Natl Chromatog Res & Anal Ctr, Dalian Inst Chem Phys, Dalian 116011, Peoples R China

Recommended Citation:
Zhang, Fei,Sun, Ting-Ting,Zhang, Yan,et al. Facile synthesis of functional gadolinium-doped CdTe quantum dots for tumor-targeted fluorescence and magnetic resonance dual-modality imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(41):7201-7209.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Zhang, Fei]'s Articles
 [Sun, Ting-Ting]'s Articles
 [Zhang, Yan]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Zhang, Fei]‘s Articles
 [Sun, Ting-Ting]‘s Articles
 [Zhang, Yan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace