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题名: In vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences
作者: Sun, Dongxue1;  Zhu, Liangliang2;  Xiao, Ling3;  Xia, Yangliu4;  Ge, Guangbo4;  Cao, Yunfeng4;  Wu, Yan2;  Yin, Jun1;  Yang, Ling4
关键词: Armillarisin A ;  liver microsomal glucuronidation ;  species difference ;  UDP-glucuronosyltranferases
刊名: XENOBIOTICA
发表日期: 2014-11-01
DOI: 10.3109/00498254.2014.927084
卷: 44, 期:11, 页:988-995
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ;  Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ;  Toxicology
英文摘要: 1. This study is performed to investigate liver microsomal glucuronidation of Armillarisin A (A.A), an effective cholagogue drug, aiming at characterizing the involved UDP-glucuronosyltranferases (UGT) and revealing potential species differences.
关键词[WOS]: TANDEM MASS-SPECTROMETRY ;  MESSENGER-RNA EXPRESSION ;  HUMAN LIVER ;  INTESTINAL GLUCURONIDATION ;  DRUG GLUCURONIDATION ;  CYTOCHROME-P450 ;  INHIBITION ;  METABOLISM ;  ISOFORMS ;  IDENTIFICATION
语种: 英语
WOS记录号: WOS:000343080900004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145893
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Dept Tradit Chinese Med Resources, Shenyang, Peoples R China
2.Anqing Normal Univ, Sch Life Sci, Lab Drug & Food Safety Evaluat, Anqing, Peoples R China
3.Anqing Normal Univ, Lab Resources & Environm, Anqing, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China

Recommended Citation:
Sun, Dongxue,Zhu, Liangliang,Xiao, Ling,et al. In vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences[J]. XENOBIOTICA,2014,44(11):988-995.
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