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Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity
Yao, Ziang1; Wu, Haige1,2; Zhang, Shengxia1; Du, Yuguang2
KeywordKappa-carrageenan Oligosaccharides Anti-tumor Anti-angiogenesis Cd 105
Source PublicationCARBOHYDRATE POLYMERS
2014-01-30
DOI10.1016/j.carbpol.2013.09.055
Volume101Pages:359-367
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS Research AreaChemistry ; Polymer Science
WOS KeywordIN-VITRO ; ANTICOAGULANT ACTIVITY ; INHIBITS ANGIOGENESIS ; VIVO ; THERAPY ; GROWTH ; CANCER ; TUMOR ; GIGARTINALES ; ANTITUMOR
AbstractThe mixture of kappa-neocarrabiose-sulfate, kappa-neocarrahexaose-sulfate and kappa-neocarraoctaose-sulfate were prepared from kappa-carrageenan with enzyme. The anti-tumor and anti-angiogenic activity of obtained kappa-carrageenan oligosaccharides (KOS), were explored. The results showed that KOS could inhibit the proliferation, migration and tube formation of ECV304 cells, and could inhibit the growth of new vessels in CAM model. KOS displayed strong anti-tumor activity in both S180 and MCF-7 xenograft models. Only human CD105 was detected in MCF-7 xenograft tumor, moreover KOS could decrease the growing of new blood vessels derived from tumor cell. Real-time PCR results showed that KOS could suppress the mRNA expression of human VEGF, bFGF, bFGFR and CD105 in MCF-7 xenograft tumor. All these results indicated that KOS has anti-tumor and anti-angiogenic activity in vivo and in vitro. Especially K has the potency to inhibit the differentiation of tumor cell to blood vessel endothelial cell. (C) 2013 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000330494800043
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/145912
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Univ, Sch Life Sci & Technol, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Yao, Ziang,Wu, Haige,Zhang, Shengxia,et al. Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity[J]. CARBOHYDRATE POLYMERS,2014,101:359-367.
APA Yao, Ziang,Wu, Haige,Zhang, Shengxia,&Du, Yuguang.(2014).Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity.CARBOHYDRATE POLYMERS,101,359-367.
MLA Yao, Ziang,et al."Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity".CARBOHYDRATE POLYMERS 101(2014):359-367.
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