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题名: Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity
作者: Yao, Ziang1;  Wu, Haige1, 2;  Zhang, Shengxia1;  Du, Yuguang2
关键词: kappa-Carrageenan oligosaccharides ;  Anti-tumor ;  Anti-angiogenesis ;  CD 105
刊名: CARBOHYDRATE POLYMERS
发表日期: 2014-01-30
DOI: 10.1016/j.carbpol.2013.09.055
卷: 101, 页:359-367
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: The mixture of kappa-neocarrabiose-sulfate, kappa-neocarrahexaose-sulfate and kappa-neocarraoctaose-sulfate were prepared from kappa-carrageenan with enzyme. The anti-tumor and anti-angiogenic activity of obtained kappa-carrageenan oligosaccharides (KOS), were explored. The results showed that KOS could inhibit the proliferation, migration and tube formation of ECV304 cells, and could inhibit the growth of new vessels in CAM model. KOS displayed strong anti-tumor activity in both S180 and MCF-7 xenograft models. Only human CD105 was detected in MCF-7 xenograft tumor, moreover KOS could decrease the growing of new blood vessels derived from tumor cell. Real-time PCR results showed that KOS could suppress the mRNA expression of human VEGF, bFGF, bFGFR and CD105 in MCF-7 xenograft tumor. All these results indicated that KOS has anti-tumor and anti-angiogenic activity in vivo and in vitro. Especially K has the potency to inhibit the differentiation of tumor cell to blood vessel endothelial cell. (C) 2013 Elsevier Ltd. All rights reserved.
关键词[WOS]: IN-VITRO ;  ANTICOAGULANT ACTIVITY ;  INHIBITS ANGIOGENESIS ;  VIVO ;  THERAPY ;  GROWTH ;  CANCER ;  TUMOR ;  GIGARTINALES ;  ANTITUMOR
语种: 英语
WOS记录号: WOS:000330494800043
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145912
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ, Sch Life Sci & Technol, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Yao, Ziang,Wu, Haige,Zhang, Shengxia,et al. Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity[J]. CARBOHYDRATE POLYMERS,2014,101:359-367.
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