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Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity
Yao, Ziang1; Wu, Haige1,2; Zhang, Shengxia1; Du, Yuguang2
关键词Kappa-carrageenan Oligosaccharides Anti-tumor Anti-angiogenesis Cd 105
刊名CARBOHYDRATE POLYMERS
2014-01-30
DOI10.1016/j.carbpol.2013.09.055
101页:359-367
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Chemistry ; Polymer Science
关键词[WOS]IN-VITRO ; ANTICOAGULANT ACTIVITY ; INHIBITS ANGIOGENESIS ; VIVO ; THERAPY ; GROWTH ; CANCER ; TUMOR ; GIGARTINALES ; ANTITUMOR
英文摘要The mixture of kappa-neocarrabiose-sulfate, kappa-neocarrahexaose-sulfate and kappa-neocarraoctaose-sulfate were prepared from kappa-carrageenan with enzyme. The anti-tumor and anti-angiogenic activity of obtained kappa-carrageenan oligosaccharides (KOS), were explored. The results showed that KOS could inhibit the proliferation, migration and tube formation of ECV304 cells, and could inhibit the growth of new vessels in CAM model. KOS displayed strong anti-tumor activity in both S180 and MCF-7 xenograft models. Only human CD105 was detected in MCF-7 xenograft tumor, moreover KOS could decrease the growing of new blood vessels derived from tumor cell. Real-time PCR results showed that KOS could suppress the mRNA expression of human VEGF, bFGF, bFGFR and CD105 in MCF-7 xenograft tumor. All these results indicated that KOS has anti-tumor and anti-angiogenic activity in vivo and in vitro. Especially K has the potency to inhibit the differentiation of tumor cell to blood vessel endothelial cell. (C) 2013 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000330494800043
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/145912
专题中国科学院大连化学物理研究所
作者单位1.Dalian Univ, Sch Life Sci & Technol, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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Yao, Ziang,Wu, Haige,Zhang, Shengxia,et al. Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity[J]. CARBOHYDRATE POLYMERS,2014,101:359-367.
APA Yao, Ziang,Wu, Haige,Zhang, Shengxia,&Du, Yuguang.(2014).Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity.CARBOHYDRATE POLYMERS,101,359-367.
MLA Yao, Ziang,et al."Enzymatic preparation of kappa-carrageenan oligosaccharides and their anti-angiogenic activity".CARBOHYDRATE POLYMERS 101(2014):359-367.
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