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Facile construction of macroporous hybrid monoliths via thiol-methacrylate Michael addition click reaction for capillary liquid chromatography
Lin, Hui1,2; Ou, Junjie1; Liu, Zhongshan1,2; Wang, Hongwei1,2; Dong, Jing1; Zou, Hanfa1
KeywordPolyhedral Oligomeric Silsesquioxane (Poss) Hybrid Monolith Thiol-methacrylate Michael Addition Reaction Click Chemistry Capillary Liquid Chromatography
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2015-01-30
DOI10.1016/j.chroma.2014.12.031
Volume1379Pages:34-42
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordPOLYHEDRAL OLIGOMERIC SILSESQUIOXANES ; RING-OPENING POLYMERIZATION ; STATIONARY-PHASE ; SILICA MONOLITHS ; COLUMNS ; CHEMISTRY ; ELECTROCHROMATOGRAPHY ; PERFORMANCE ; SEPARATION ; PHOTOPOLYMERIZATION
AbstractA facile approach based on thiol-methacrylate Michael addition click reaction was developed for construction of porous hybrid monolithic materials. Three hybrid monoliths were prepared via thiol-methacrylate click polymerization by using methacrylate-polyhedral oligomeric silsesquioxane (POSS) (cage mixture, n = 8, 10, 12, POSS-MA) and three multi-thiol crosslinkers, 1,6-hexanedithiol (HDT), trimethylolpropane tris(3-mercaptopropionate) (TPTM) and pentaerythritol tetrakis(3-mercaptopropionate) (PTM), respectively, in the presence of porogenic solvents (n-propanol and PEG 200) and a catalyst (dimethylphenylphosphine, DMPP). The obtained monoliths possessed high thermal and chemical stabilities. Besides, they all exhibited high column efficiencies and excellent separation abilities in capillary liquid chromatography (cLC). The highest column efficiency could reach ca. 195,000 N/m for butylbenzene on the monolith prepared with POSS-MA and TPTM (monolith POSS-TPTM) in reversed-phase (RP) mode at 0.64 mm/s. Good chromatographic performance were all achieved in the separations of polycyclic aromatic hydrocarbons (PAHs), phenols, anilines, EPA 610 as well as bovine serum albumin (BSA) digest. The high column efficiencies in the range of 51,400-117,000 N/m (achieved on the monolith POSS-PTM in RP mode) convincingly demonstrated the high separation abilities of these thiol-methacrylate based hybrid monoliths. All the results demonstrated the feasibility of the phosphines catalyzed thiol-methacrylate Michael addition click reaction in fabrication of monolithic columns with high efficiency for cLC applications. (C) 2014 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000349197300005
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/145936
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Lin, Hui,Ou, Junjie,Liu, Zhongshan,et al. Facile construction of macroporous hybrid monoliths via thiol-methacrylate Michael addition click reaction for capillary liquid chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2015,1379:34-42.
APA Lin, Hui,Ou, Junjie,Liu, Zhongshan,Wang, Hongwei,Dong, Jing,&Zou, Hanfa.(2015).Facile construction of macroporous hybrid monoliths via thiol-methacrylate Michael addition click reaction for capillary liquid chromatography.JOURNAL OF CHROMATOGRAPHY A,1379,34-42.
MLA Lin, Hui,et al."Facile construction of macroporous hybrid monoliths via thiol-methacrylate Michael addition click reaction for capillary liquid chromatography".JOURNAL OF CHROMATOGRAPHY A 1379(2015):34-42.
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