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题名: In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction
作者: Songkroh, Titima1, 2;  Xie, Hongguo1;  Yu, Weiting1;  Lv, Guojun1;  Liu, Xiudong3;  Wang, Lin4;  Sun, Guangwei1;  Xu, Xiaoxi1;  Ma, Xiaojun1
关键词: Chitosan-based hydrogels ;  Biological lung volume reduction ;  Lung sealants ;  Emphysema
刊名: SCIENCE BULLETIN
发表日期: 2015
DOI: 10.1007/s11434-014-0548-3
卷: 60, 期:2, 页:235-240
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Biological lung volume reduction (BLVR) using lung sealant has received more attention recently as a new non-surgical approach to emphysema treatment. Many tissue sealants have been studied but only a few have been proposed for BLVR. In this work, we prepared in situ forming chitosan-based hydrogels (CSG) using covalent cross-linking of chitosan and genipin in the cooperation of ionic interaction between chitosan and sodium orthophosphate hydrate (Na3PO4 center dot 12H(2)O) and characterized by Fourier transform infrared spectroscopy, scanning electron microscopy and rheological methods. CSG showed short gelation time (8 min), high swelling ratio (> 100 %) and non-toxicity (3T3 mouse fibroblast cell viability > 80 %) under physiological conditions. The application of lung sealant for BLVR was tested in a Chinese dog and evaluated by chest computed tomography. After 3 weeks of the installation of CSG in bronchopulmonary segment, the gel formation was detected at a localized region of bronchi and the local atelectasis occurred. Our findings indicate that this chitosan-based hydrogel is a promising new candidate for use as a lung sealant for BLVR.
关键词[WOS]: ADVANCED EMPHYSEMA ;  TISSUE ;  BIOMATERIALS ;  DELIVERY ;  THERAPY ;  GELS
语种: 英语
WOS记录号: WOS:000348927000009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145952
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
4.Dalian Univ, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China

Recommended Citation:
Songkroh, Titima,Xie, Hongguo,Yu, Weiting,et al. In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction[J]. SCIENCE BULLETIN,2015,60(2):235-240.
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