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In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction
Songkroh, Titima1,2; Xie, Hongguo1; Yu, Weiting1; Lv, Guojun1; Liu, Xiudong3; Wang, Lin4; Sun, Guangwei1; Xu, Xiaoxi1; Ma, Xiaojun1
关键词Chitosan-based Hydrogels Biological Lung Volume Reduction Lung Sealants Emphysema
刊名SCIENCE BULLETIN
2015
DOI10.1007/s11434-014-0548-3
60期:2页:235-240
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ADVANCED EMPHYSEMA ; TISSUE ; BIOMATERIALS ; DELIVERY ; THERAPY ; GELS
英文摘要Biological lung volume reduction (BLVR) using lung sealant has received more attention recently as a new non-surgical approach to emphysema treatment. Many tissue sealants have been studied but only a few have been proposed for BLVR. In this work, we prepared in situ forming chitosan-based hydrogels (CSG) using covalent cross-linking of chitosan and genipin in the cooperation of ionic interaction between chitosan and sodium orthophosphate hydrate (Na3PO4 center dot 12H(2)O) and characterized by Fourier transform infrared spectroscopy, scanning electron microscopy and rheological methods. CSG showed short gelation time (8 min), high swelling ratio (> 100 %) and non-toxicity (3T3 mouse fibroblast cell viability > 80 %) under physiological conditions. The application of lung sealant for BLVR was tested in a Chinese dog and evaluated by chest computed tomography. After 3 weeks of the installation of CSG in bronchopulmonary segment, the gel formation was detected at a localized region of bronchi and the local atelectasis occurred. Our findings indicate that this chitosan-based hydrogel is a promising new candidate for use as a lung sealant for BLVR.
语种英语
WOS记录号WOS:000348927000009
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/145952
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
4.Dalian Univ, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China
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GB/T 7714
Songkroh, Titima,Xie, Hongguo,Yu, Weiting,et al. In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction[J]. SCIENCE BULLETIN,2015,60(2):235-240.
APA Songkroh, Titima.,Xie, Hongguo.,Yu, Weiting.,Lv, Guojun.,Liu, Xiudong.,...&Ma, Xiaojun.(2015).In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction.SCIENCE BULLETIN,60(2),235-240.
MLA Songkroh, Titima,et al."In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction".SCIENCE BULLETIN 60.2(2015):235-240.
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