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Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice
Huang, Huimei1,2; Yang, Yongge3; Lv, Chao2; Chang, Wanlin2; Peng, Chengcheng4; Wang, Shuping1; Ge, Guangbo5; Han, Lin1; Zhang, Weidong1,2,3; Liu, Runhui1,2
KeywordBufadienolides Shexiang Baoxin Pill Pharmacokinetic Tissue Distribution Lc-esi-ms/ms
Source PublicationJOURNAL OF ETHNOPHARMACOLOGY
2015-02-23
DOI10.1016/jjep.2014.07.056
Volume161Pages:175-185
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS KeywordTANDEM MASS-SPECTROMETRY ; RAT PLASMA ; TOAD VENOM ; CHROMATOGRAPHY ; EXTRACT ; HPLC ; CONSTITUENTS ; IONIZATION ; INDUCTION ; CHANSU
AbstractEthnopharmacological relevance: Shexiang Baoxin Pill (SBP) is a well-known composite formula of traditional Chinese medicine (TCM), widely used to treat cardiovascular diseases such as angina pectoris and myocardial infarction. Bufadienolides are major active compounds of Venenum Bufonis, which is one of the seven materiamedicas that comprise the Shexiang Baoxin Pill. Previous pharmacokinetics studies of bufadienolides have typically used a single medicinal material delivered to rats. In this study, we have chosen the mouse, a more proper animal model than the rat, to investigate the in vivo pharmacokinetics and tissue distribution of bufadienolides from the Shexiang Baoxin Pill.
Language英语
WOS IDWOS:000349731100022
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/145985
Collection中国科学院大连化学物理研究所
Affiliation1.Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
2.Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108, Fujian, Peoples R China
3.Beijing Mil Command Gen Hosp, Dept Clin Pharmacol, Beijing 100700, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Huang, Huimei,Yang, Yongge,Lv, Chao,et al. Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice[J]. JOURNAL OF ETHNOPHARMACOLOGY,2015,161:175-185.
APA Huang, Huimei.,Yang, Yongge.,Lv, Chao.,Chang, Wanlin.,Peng, Chengcheng.,...&Liu, Runhui.(2015).Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice.JOURNAL OF ETHNOPHARMACOLOGY,161,175-185.
MLA Huang, Huimei,et al."Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice".JOURNAL OF ETHNOPHARMACOLOGY 161(2015):175-185.
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