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题名: Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice
作者: Huang, Huimei1, 2;  Yang, Yongge3;  Lv, Chao2;  Chang, Wanlin2;  Peng, Chengcheng4;  Wang, Shuping1;  Ge, Guangbo5;  Han, Lin1;  Zhang, Weidong1, 2, 3;  Liu, Runhui1, 2
关键词: Bufadienolides ;  Shexiang Baoxin Pill ;  Pharmacokinetic ;  Tissue distribution ;  LC-ESI-MS/MS
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2015-02-23
DOI: 10.1016/jjep.2014.07.056
卷: 161, 页:175-185
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Integrative & Complementary Medicine ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy ;  Integrative & Complementary Medicine
英文摘要: Ethnopharmacological relevance: Shexiang Baoxin Pill (SBP) is a well-known composite formula of traditional Chinese medicine (TCM), widely used to treat cardiovascular diseases such as angina pectoris and myocardial infarction. Bufadienolides are major active compounds of Venenum Bufonis, which is one of the seven materiamedicas that comprise the Shexiang Baoxin Pill. Previous pharmacokinetics studies of bufadienolides have typically used a single medicinal material delivered to rats. In this study, we have chosen the mouse, a more proper animal model than the rat, to investigate the in vivo pharmacokinetics and tissue distribution of bufadienolides from the Shexiang Baoxin Pill.
关键词[WOS]: TANDEM MASS-SPECTROMETRY ;  RAT PLASMA ;  TOAD VENOM ;  CHROMATOGRAPHY ;  EXTRACT ;  HPLC ;  CONSTITUENTS ;  IONIZATION ;  INDUCTION ;  CHANSU
语种: 英语
WOS记录号: WOS:000349731100022
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145985
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
2.Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108, Fujian, Peoples R China
3.Beijing Mil Command Gen Hosp, Dept Clin Pharmacol, Beijing 100700, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China

Recommended Citation:
Huang, Huimei,Yang, Yongge,Lv, Chao,et al. Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice[J]. JOURNAL OF ETHNOPHARMACOLOGY,2015,161:175-185.
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