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题名: Realization of In-Source Collision-Induced Dissociation in Single-Photon Ionization Time-of-Flight Mass Spectrometry and Its Application for Differentiation of Isobaric Compounds
作者: Hua, Lei1;  Hou, Keyong1;  Chen, Ping1;  Xie, Yuanyuan1, 2;  Jiang, Jichun1, 2;  Wang, Yan1, 2;  Wang, Weiguo1;  Li, Haiyang1
刊名: ANALYTICAL CHEMISTRY
发表日期: 2015-02-17
DOI: 10.1021/ac5043768
卷: 87, 期:4, 页:2427-2433
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Single-photon ionization mass spectrometry (SPI-MS) is a versatile and powerful analytical technique for online and real-time analysis of organic species; however, it is confronted with an intrinsic drawback of lacking structural information on the investigated molecules, let alone differentiation of isobaric compounds. In this work, we describe a first attempt to integrate in-source collision-induced dissociation (CID) to the SPI ion source in a SPI-MS instrument. The in-source CID was accomplished by elevating the pressure in the ion source to medium vacuum pressure (MVP) and raising the extraction voltage. With the aid of in-source CID, both the SPI-induced molecular ion and CID-generated fragment ion mass spectra can be obtained to endue each analyte with its unique spectrometric fingerprint. The capability for differentiation of isobaric compounds is demonstrated by analyzing two groups of isobaric compounds with molecular weights of 72 and 106 Da, respectively, and quantitative analysis of p-xylene and ethylbenzene in gas mixture. As a result, isobaric compounds with different characteristic fragment ions or appearance energies can be successfully distinguished. The work presents a feasible method for practical applications of SPI-MS to differentiate isobaric compounds conveniently and rapidly without MS/MS technique or coupling additional separation technologies.
关键词[WOS]: VACUUM-ULTRAVIOLET LAMP ;  EVOLVED GAS-ANALYSIS ;  SPI-IT-TOFMS ;  ORGANIC-COMPOUNDS ;  SOURCE FRAGMENTATION ;  ONLINE ANALYSIS ;  CRUDE OILS ;  PYROLYSIS ;  LIGHT ;  IONS
语种: 英语
WOS记录号: WOS:000349806200057
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146001
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China

Recommended Citation:
Hua, Lei,Hou, Keyong,Chen, Ping,et al. Realization of In-Source Collision-Induced Dissociation in Single-Photon Ionization Time-of-Flight Mass Spectrometry and Its Application for Differentiation of Isobaric Compounds[J]. ANALYTICAL CHEMISTRY,2015,87(4):2427-2433.
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