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题名: Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae
作者: Zhang, Jingxiao1;  Li, Yan1;  Chen, Su-Shing2, 3;  Zhang, Lilei4;  Wang, Jinghui1;  Yang, Yinfeng1;  Zhang, Shuwei1;  Pan, Yanqiu1;  Wang, Yonghua5;  Yang, Ling6
刊名: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
发表日期: 2015-02-01
DOI: 10.3390/ijms16022913
卷: 16, 期:2, 页:2913-2941
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemistry & Molecular Biology ;  Chemistry, Multidisciplinary
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. Here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb Folium Eriobotryae, a widely used clinical anti-inflammatory botanic drug. The results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. In addition, via systematic network analyses, their targets are identified to be 43 inflammation-associated proteins including especially COX2, ALOX5, PPARG, TNF and RELA that are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway, the rheumatoid arthritis pathway and NF-kappa B signaling pathway. All these demonstrate that the integrated systems pharmacology method provides not only an effective tool to illustrate the anti-inflammatory mechanisms of herbs, but also a new systems-based approach for drug discovery from, but not limited to, herbs, especially when combined with further experimental validations.
关键词[WOS]: NF-KAPPA-B ;  TRADITIONAL CHINESE MEDICINE ;  JAPONICA THUNB. LINDL. ;  INFLAMMATORY DISEASES ;  CHLOROGENIC ACID ;  DRUG DISCOVERY ;  URSOLIC ACID ;  ORAL BIOAVAILABILITY ;  THERAPEUTIC TARGETS ;  CHRONIC-BRONCHITIS
语种: 英语
WOS记录号: WOS:000350333600038
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146032
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ Technol, Key Lab Ind Ecol & Environm Engn MOE, Fac Chem Environm & Biol Sci & Technol, Dalian 116024, Peoples R China
2.Univ Florida, Syst Biol Lab, Gainesville, FL 32608 USA
3.Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32608 USA
4.Hubei Univ Nationalities, Sch Chem & Environm Engn, Enshi 445000, Peoples R China
5.Northwest A&F Univ, Coll Life Sci, Ctr Bioinformat, Yangling 712100, Peoples R China
6.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China

Recommended Citation:
Zhang, Jingxiao,Li, Yan,Chen, Su-Shing,et al. Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015,16(2):2913-2941.
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