中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Injectable In situ Forming Chitosan-Based Hydrogels For Curcumin Delivery
作者: Songkroh, Titima1, 2;  Xie, Hongguo1;  Yu, Weiting1;  Liu, Xiudong3;  Sun, Guangwei1;  Xu, Xiaoxi1;  Ma, Xiaojun1
关键词: chitosan ;  hydrogel ;  curcumin ;  drug delivery
刊名: MACROMOLECULAR RESEARCH
发表日期: 2015
DOI: 10.1007/s13233-015-3006-4
卷: 23, 期:1, 页:53-59
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Polymer Science
研究领域[WOS]: Polymer Science
英文摘要: In this paper, a series of injectable in situ forming chitosan-based hydrogels were prepared by chemical crosslinking of chitosan and genipin with the cooperation of ionic bonds between chitosan and sodium salts at room temperature. Four hydrogels (A, B, C, and D) were obtained by mixing chitosan, genipin and a sodium salt of trisodium phosphate (Na3PO4 center dot 12H(2)O), sodium sulfate (Na2SO4), sodium sulfite (Na2SO3), or sodium bicarbonate (NaH-CO3) and examined for their characteristics, morphology, and rheological properties. Their cell viability assays exhibited low toxicity and the localized in situ gel formation was detected after subcutaneous injections in rat. Curcumin which possesses many pharmaceutical potentials but has low bioavailability, was chosen as a drug model. In vitro curcumin release profiles exhibit sustained release properties with initial burst release for all hydrogels with about 3 to 6 times higher cumulative release than other gel controls. The results of this study demonstrate that our hydrogels have a potential as local curcumin carriers.
关键词[WOS]: DRUG-DELIVERY ;  BIOLOGICAL-ACTIVITIES ;  BIOMATERIALS ;  DESIGN ;  CANCER ;  GELS ;  NANOPARTICLES ;  SYSTEMS ;  GENIPIN ;  PH
语种: 英语
WOS记录号: WOS:000350361900008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146043
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, DICP, Dalian 116023, Liaoning, Peoples R China
2.UCAS, Beijing 100049, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Liaoning, Peoples R China

Recommended Citation:
Songkroh, Titima,Xie, Hongguo,Yu, Weiting,et al. Injectable In situ Forming Chitosan-Based Hydrogels For Curcumin Delivery[J]. MACROMOLECULAR RESEARCH,2015,23(1):53-59.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Songkroh, Titima]'s Articles
 [Xie, Hongguo]'s Articles
 [Yu, Weiting]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Songkroh, Titima]‘s Articles
 [Xie, Hongguo]‘s Articles
 [Yu, Weiting]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace