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题名: Influence of Microemulsion-Mucin Interaction on the Fate of Microemulsions Diffusing through Pig Gastric Mucin Solutions
作者: Zhang, Jianbin1, 2;  Lv, Yan1, 2;  Wang, Bing1, 2;  Zhao, Shan1, 2;  Tan, Mingqian1;  Lv, Guojun1;  Ma, Xiaojun1
关键词: microemulsion ;  mucin ;  interaction ;  fluorescence resonance energy transfer (FRET) ;  fluorescence recovery after photobleaching (FRAP) ;  Franz diffusion cell
刊名: MOLECULAR PHARMACEUTICS
发表日期: 2015-03-01
DOI: 10.1021/mp500475y
卷: 12, 期:3, 页:695-705
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Medicine, Research & Experimental ;  Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ;  Pharmacology & Pharmacy
英文摘要: Mucus layer, a selective diffusion barrier, has an important effect on the fate of drug delivery systems in the gastrointestinal tract. To study the fate of microemulsions in the mucus layer, four microemulsion formulations with different particle sizes and lipid compositions were prepared. The microemulsion-mucin interaction was demonstrated by the fluorescence resonance energy transfer (FRET) method. Moreover, the microemulsions were observed aggregated into micron-sized emulsions by laser confocal microscopy. We concluded the microemulsion-mucin interaction not only led to microemulsions closely adhered to mucins but also destroyed the structure of microemulsions. At last, the diffusion of blank microemulsions and microemulsion-carried drugs (resveratrol and hymecromone) through mucin solutions was determined by the fluorescence recovery after photobleaching (FRAP) method and the Franz diffusion cell method. The results demonstrated the diffusion of microemulsions was significantly hindered by mucin solutions. The particle size of microemulsions had a negligible effect on the diffusion coefficients. However, the type of lipid played an important role, which could form hydrophobic interactions with mucins. Interestingly, microemulsion-carried drugs with different core/shell locations seemed to suffer different fates in the mucin solutions. The drug incorporated in the oil core of microemulsions, resveratrol, was transported through the mucus layer by the carriers, while the drug incorporated in the surfactant shell of microemulsions, hymecromone, was separated from the carriers and diffused toward the epithelium in the form of free molecules.
关键词[WOS]: DELIVERY SYSTEMS SMEDDS ;  X-RAY-SCATTERING ;  DRUG-DELIVERY ;  GASTROINTESTINAL MUCUS ;  POLYMERIC NANOPARTICLES ;  ORAL BIOAVAILABILITY ;  IN-VIVO ;  DIGESTION ;  FORMULATIONS ;  TRANSLOCATION
语种: 英语
WOS记录号: WOS:000350390900004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146046
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China

Recommended Citation:
Zhang, Jianbin,Lv, Yan,Wang, Bing,et al. Influence of Microemulsion-Mucin Interaction on the Fate of Microemulsions Diffusing through Pig Gastric Mucin Solutions[J]. MOLECULAR PHARMACEUTICS,2015,12(3):695-705.
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