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A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma
Zhang, Weijian1; Zhou, Lina2; Yin, Peiyuan2; Wang, Jinbing3; Lu, Xin2; Wang, Xiaomei1; Chen, Jianguo3; Lin, Xiaohui1; Xu, Guowang2
刊名SCIENTIFIC REPORTS
2015-03-11
DOI10.1038/srep08984
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GENE-EXPRESSION DATA ; TIME-SERIES DATA ; URSODEOXYCHOLIC ACID ; MASS-SPECTROMETRY ; DOWN-REGULATION ; RAT-LIVER ; DISCOVERY ; HEPATOCARCINOGENESIS ; PATHOGENESIS ; HOMEOSTASIS
英文摘要Dynamic metabolomics studies can provide a systematic view of the metabolic trajectory during disease development and drug treatment and reveal the nature of biological processes at metabolic level. To extract important information in a systematic time dimension rather than at isolated time points, a weighted method based on the means and variations along the time points was proposed and first applied to previously published rat model data. The method was subsequently extended and applied to prospective metabolomics data analysis of hepatocellular carcinoma (HCC). Permutation was employed for noise filtering and false discovery rate (FDR) was used for parameter optimization during the feature selection. Long-term elevated serum bile acids were identified as risk factors for HCC development.
语种英语
WOS记录号WOS:000351138000006
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146049
专题中国科学院大连化学物理研究所
作者单位1.Dalian Univ Technol, Sch Comp Sci & Technol, Dalian, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
3.Qidong Liver Canc Inst, Qidong 226200, Peoples R China
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GB/T 7714
Zhang, Weijian,Zhou, Lina,Yin, Peiyuan,et al. A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma[J]. SCIENTIFIC REPORTS,2015,5.
APA Zhang, Weijian.,Zhou, Lina.,Yin, Peiyuan.,Wang, Jinbing.,Lu, Xin.,...&Xu, Guowang.(2015).A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma.SCIENTIFIC REPORTS,5.
MLA Zhang, Weijian,et al."A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma".SCIENTIFIC REPORTS 5(2015).
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