DICP OpenIR
A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma
Zhang, Weijian1; Zhou, Lina2; Yin, Peiyuan2; Wang, Jinbing3; Lu, Xin2; Wang, Xiaomei1; Chen, Jianguo3; Lin, Xiaohui1; Xu, Guowang2
Source PublicationSCIENTIFIC REPORTS
2015-03-11
DOI10.1038/srep08984
Volume5
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordGENE-EXPRESSION DATA ; TIME-SERIES DATA ; URSODEOXYCHOLIC ACID ; MASS-SPECTROMETRY ; DOWN-REGULATION ; RAT-LIVER ; DISCOVERY ; HEPATOCARCINOGENESIS ; PATHOGENESIS ; HOMEOSTASIS
AbstractDynamic metabolomics studies can provide a systematic view of the metabolic trajectory during disease development and drug treatment and reveal the nature of biological processes at metabolic level. To extract important information in a systematic time dimension rather than at isolated time points, a weighted method based on the means and variations along the time points was proposed and first applied to previously published rat model data. The method was subsequently extended and applied to prospective metabolomics data analysis of hepatocellular carcinoma (HCC). Permutation was employed for noise filtering and false discovery rate (FDR) was used for parameter optimization during the feature selection. Long-term elevated serum bile acids were identified as risk factors for HCC development.
Language英语
WOS IDWOS:000351138000006
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146049
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Univ Technol, Sch Comp Sci & Technol, Dalian, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
3.Qidong Liver Canc Inst, Qidong 226200, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Weijian,Zhou, Lina,Yin, Peiyuan,et al. A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma[J]. SCIENTIFIC REPORTS,2015,5.
APA Zhang, Weijian.,Zhou, Lina.,Yin, Peiyuan.,Wang, Jinbing.,Lu, Xin.,...&Xu, Guowang.(2015).A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma.SCIENTIFIC REPORTS,5.
MLA Zhang, Weijian,et al."A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma".SCIENTIFIC REPORTS 5(2015).
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