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题名: A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma
作者: Zhang, Weijian1;  Zhou, Lina2;  Yin, Peiyuan2;  Wang, Jinbing3;  Lu, Xin2;  Wang, Xiaomei1;  Chen, Jianguo3;  Lin, Xiaohui1;  Xu, Guowang2
刊名: SCIENTIFIC REPORTS
发表日期: 2015-03-11
DOI: 10.1038/srep08984
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Dynamic metabolomics studies can provide a systematic view of the metabolic trajectory during disease development and drug treatment and reveal the nature of biological processes at metabolic level. To extract important information in a systematic time dimension rather than at isolated time points, a weighted method based on the means and variations along the time points was proposed and first applied to previously published rat model data. The method was subsequently extended and applied to prospective metabolomics data analysis of hepatocellular carcinoma (HCC). Permutation was employed for noise filtering and false discovery rate (FDR) was used for parameter optimization during the feature selection. Long-term elevated serum bile acids were identified as risk factors for HCC development.
关键词[WOS]: GENE-EXPRESSION DATA ;  TIME-SERIES DATA ;  URSODEOXYCHOLIC ACID ;  MASS-SPECTROMETRY ;  DOWN-REGULATION ;  RAT-LIVER ;  DISCOVERY ;  HEPATOCARCINOGENESIS ;  PATHOGENESIS ;  HOMEOSTASIS
语种: 英语
WOS记录号: WOS:000351138000006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146049
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ Technol, Sch Comp Sci & Technol, Dalian, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
3.Qidong Liver Canc Inst, Qidong 226200, Peoples R China

Recommended Citation:
Zhang, Weijian,Zhou, Lina,Yin, Peiyuan,et al. A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma[J]. SCIENTIFIC REPORTS,2015,5.
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