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Regulating cell behaviors on micropillar topographies affected by interfacial energy
Gao, Xinghua1; Chau, Yeung Yeung2; Xie, Jiao5; Wan, Jun1,6; Ren, Yanxiao4; Qin, Jianhua3; Wen, Weijia1,2,4,5
刊名RSC ADVANCES
2015
DOI10.1039/c5ra02084k
5期:29页:22916-22922
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]MESENCHYMAL STEM-CELLS ; DIFFERENTIAL REGULATION ; STIFFNESS ; SURFACES ; ADHESION ; LINEAGE ; SIZE ; ORGANIZATION ; ORIENTATION ; PLATFORMS
英文摘要Micro/ sub-micro substrate topography plays an important role in cell morphology and function. By localizing individual hepatic stellate cells on different micropillar topographies, we found that the cell morphology was thus greatly influenced due to the cell location. As a simple physical model showed, the morphological response of cells to micropillar topography can be triggered by a minimum interfacial energy. In particular, an established topography with a spacing of 2.5 mu m and pillar diameter of 5 mu m was found to be able to change the expression of E-cadherin and alpha-smooth muscle actin. It suggested that the size of the established topography might be closely related to cell epithelial-mesenchymal transition. This study has potential significance in mimicking the size of Disse's space in pathological conditions and advanced the understanding of the physical mechanisms of liver fibrosis and cirrhosis.
语种英语
WOS记录号WOS:000350643700074
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146065
专题中国科学院大连化学物理研究所
作者单位1.Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Med Ctr, Biomed Res Inst, Shenzhen, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Phys, Kowloon, Hong Kong, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
4.Hong Kong Univ Sci & Technol, Shenzhen Res Inst, Shenzhen, Peoples R China
5.Chongqing Univ, Coll Phys, Soft Matter & Interdisciplinary Res Inst, Chongqing 630044, Peoples R China
6.Hong Kong Univ Sci & Technol, Div Iife Sci, Kowloon, Hong Kong, Peoples R China
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GB/T 7714
Gao, Xinghua,Chau, Yeung Yeung,Xie, Jiao,et al. Regulating cell behaviors on micropillar topographies affected by interfacial energy[J]. RSC ADVANCES,2015,5(29):22916-22922.
APA Gao, Xinghua.,Chau, Yeung Yeung.,Xie, Jiao.,Wan, Jun.,Ren, Yanxiao.,...&Wen, Weijia.(2015).Regulating cell behaviors on micropillar topographies affected by interfacial energy.RSC ADVANCES,5(29),22916-22922.
MLA Gao, Xinghua,et al."Regulating cell behaviors on micropillar topographies affected by interfacial energy".RSC ADVANCES 5.29(2015):22916-22922.
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