DICP OpenIR
Regulating cell behaviors on micropillar topographies affected by interfacial energy
Gao, Xinghua1; Chau, Yeung Yeung2; Xie, Jiao5; Wan, Jun1,6; Ren, Yanxiao4; Qin, Jianhua3; Wen, Weijia1,2,4,5
Source PublicationRSC ADVANCES
2015
DOI10.1039/c5ra02084k
Volume5Issue:29Pages:22916-22922
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordMESENCHYMAL STEM-CELLS ; DIFFERENTIAL REGULATION ; STIFFNESS ; SURFACES ; ADHESION ; LINEAGE ; SIZE ; ORGANIZATION ; ORIENTATION ; PLATFORMS
AbstractMicro/ sub-micro substrate topography plays an important role in cell morphology and function. By localizing individual hepatic stellate cells on different micropillar topographies, we found that the cell morphology was thus greatly influenced due to the cell location. As a simple physical model showed, the morphological response of cells to micropillar topography can be triggered by a minimum interfacial energy. In particular, an established topography with a spacing of 2.5 mu m and pillar diameter of 5 mu m was found to be able to change the expression of E-cadherin and alpha-smooth muscle actin. It suggested that the size of the established topography might be closely related to cell epithelial-mesenchymal transition. This study has potential significance in mimicking the size of Disse's space in pathological conditions and advanced the understanding of the physical mechanisms of liver fibrosis and cirrhosis.
Language英语
WOS IDWOS:000350643700074
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146065
Collection中国科学院大连化学物理研究所
Affiliation1.Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Med Ctr, Biomed Res Inst, Shenzhen, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Phys, Kowloon, Hong Kong, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
4.Hong Kong Univ Sci & Technol, Shenzhen Res Inst, Shenzhen, Peoples R China
5.Chongqing Univ, Coll Phys, Soft Matter & Interdisciplinary Res Inst, Chongqing 630044, Peoples R China
6.Hong Kong Univ Sci & Technol, Div Iife Sci, Kowloon, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Gao, Xinghua,Chau, Yeung Yeung,Xie, Jiao,et al. Regulating cell behaviors on micropillar topographies affected by interfacial energy[J]. RSC ADVANCES,2015,5(29):22916-22922.
APA Gao, Xinghua.,Chau, Yeung Yeung.,Xie, Jiao.,Wan, Jun.,Ren, Yanxiao.,...&Wen, Weijia.(2015).Regulating cell behaviors on micropillar topographies affected by interfacial energy.RSC ADVANCES,5(29),22916-22922.
MLA Gao, Xinghua,et al."Regulating cell behaviors on micropillar topographies affected by interfacial energy".RSC ADVANCES 5.29(2015):22916-22922.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Gao, Xinghua]'s Articles
[Chau, Yeung Yeung]'s Articles
[Xie, Jiao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Gao, Xinghua]'s Articles
[Chau, Yeung Yeung]'s Articles
[Xie, Jiao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Gao, Xinghua]'s Articles
[Chau, Yeung Yeung]'s Articles
[Xie, Jiao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.