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题名: Regulating cell behaviors on micropillar topographies affected by interfacial energy
作者: Gao, Xinghua1;  Chau, Yeung Yeung2;  Xie, Jiao5;  Wan, Jun1, 6;  Ren, Yanxiao4;  Qin, Jianhua3;  Wen, Weijia1, 2, 4, 5
刊名: RSC ADVANCES
发表日期: 2015
DOI: 10.1039/c5ra02084k
卷: 5, 期:29, 页:22916-22922
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Micro/ sub-micro substrate topography plays an important role in cell morphology and function. By localizing individual hepatic stellate cells on different micropillar topographies, we found that the cell morphology was thus greatly influenced due to the cell location. As a simple physical model showed, the morphological response of cells to micropillar topography can be triggered by a minimum interfacial energy. In particular, an established topography with a spacing of 2.5 mu m and pillar diameter of 5 mu m was found to be able to change the expression of E-cadherin and alpha-smooth muscle actin. It suggested that the size of the established topography might be closely related to cell epithelial-mesenchymal transition. This study has potential significance in mimicking the size of Disse's space in pathological conditions and advanced the understanding of the physical mechanisms of liver fibrosis and cirrhosis.
关键词[WOS]: MESENCHYMAL STEM-CELLS ;  DIFFERENTIAL REGULATION ;  STIFFNESS ;  SURFACES ;  ADHESION ;  LINEAGE ;  SIZE ;  ORGANIZATION ;  ORIENTATION ;  PLATFORMS
语种: 英语
WOS记录号: WOS:000350643700074
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146065
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Med Ctr, Biomed Res Inst, Shenzhen, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Phys, Kowloon, Hong Kong, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
4.Hong Kong Univ Sci & Technol, Shenzhen Res Inst, Shenzhen, Peoples R China
5.Chongqing Univ, Coll Phys, Soft Matter & Interdisciplinary Res Inst, Chongqing 630044, Peoples R China
6.Hong Kong Univ Sci & Technol, Div Iife Sci, Kowloon, Hong Kong, Peoples R China

Recommended Citation:
Gao, Xinghua,Chau, Yeung Yeung,Xie, Jiao,et al. Regulating cell behaviors on micropillar topographies affected by interfacial energy[J]. RSC ADVANCES,2015,5(29):22916-22922.
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