中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Effects of Short-Chain Chlorinated Paraffins Exposure on the Viability and Metabolism of Human Hepatoma HepG2 Cells
作者: Geng, Ningbo1, 2;  Zhang, Haijun1;  Zhang, Baoqin1;  Wu, Ping1;  Wang, Feidi1, 2;  Yu, Zhengkun1;  Chen, Jiping1
刊名: ENVIRONMENTAL SCIENCE & TECHNOLOGY
发表日期: 2015-03-03
DOI: 10.1021/es505802x
卷: 49, 期:5, 页:3076-3083
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology ;  Life Sciences & Biomedicine
类目[WOS]: Engineering, Environmental ;  Environmental Sciences
研究领域[WOS]: Engineering ;  Environmental Sciences & Ecology
英文摘要: Short-chain chlorinated paraffins (SCCPs) have attracted considerable attention for their characteristic of persistent organic pollutants. However, very limited information is available for their toxic effects at environmentally relevant doses, limiting the evaluation of their health risks. In this study, cell viability assay and targeted metabolomic approach was used to evaluate the environmental dose (<100 mu g/L) effect of SCCPs on HepG2 cells. Cell viability was found to be decreased with increases in exposure dose of SCCPs. Exposure for 48 h to C-10-CPs resulted in a significant reduction in cell viability compared with 24 h, even at 1 mu g/L. SCCPs exposure altered the intracellular redox status and caused significant metabolic disruptions. As a kind of peroxisome proliferator, SCCPs specifically stimulated the beta-oxidation of unsaturated fatty acids and long-chain fatty acids. Meanwhile, SCCPs exposure disturbed glycolysis and amino acid metabolism, and led to the up-regulation of glutamate metabolism and urea cycle. The toxic effects of SCCPs might mainly involve the perturbation of energy production, protein biosynthesis, fatty acid metabolism, and ammonia recycling.
关键词[WOS]: POLYCHLORO-N-ALKANES ;  ENVIRONMENTAL OCCURRENCE ;  SAMPLE PREPARATION ;  METABOLOMICS ;  C-10-C-13 ;  TOXICITY ;  LIVER ;  RATS ;  SEDIMENTS ;  RESPONSES
语种: 英语
WOS记录号: WOS:000350611100062
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146080
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Geng, Ningbo,Zhang, Haijun,Zhang, Baoqin,et al. Effects of Short-Chain Chlorinated Paraffins Exposure on the Viability and Metabolism of Human Hepatoma HepG2 Cells[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2015,49(5):3076-3083.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Geng, Ningbo]'s Articles
 [Zhang, Haijun]'s Articles
 [Zhang, Baoqin]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Geng, Ningbo]‘s Articles
 [Zhang, Haijun]‘s Articles
 [Zhang, Baoqin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace