DICP OpenIR
Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway
Wu, Shan1; Xu, Hui2; Peng, Jinyong1; Wang, Changyuan1; Jin, Yue1; Liu, Kexin1; Sun, Huijun1; Qin, Jianhua2
KeywordDioscin Tnf-alpha Nf-kappa b Pathways El Huvecs Monocytes
Source PublicationBIOCHIMIE
2015-03-01
DOI10.1016/j.biochi.2014.12.022
Volume110CPages:62-72
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordENDOTHELIAL-CELL-ADHESION ; ATHEROSCLEROTIC LESION ; LINKING INFLAMMATION ; LIPASE ; ACTIVATION ; ATHEROGENESIS ; MECHANISMS ; MOLECULES ; CYTOKINES ; DISEASES
AbstractThe modulation of adhesion molecule expression and the reduction of aberrant leukocyte adhesion to the endothelium are attractive approaches for treating inflammation-related vascular complications, including atherosclerosis. Dioscin has a variety of biological activities including anti-inflammatory activity. However, the molecular mechanisms behind dioscin's anti-inflammatory effects are not fully understood. In this study, we investigated the molecular mechanism involved in the effects of dioscin on inflammatory mediators in tumor necrosis factor-alpha (TNF-alpha)-stimulated human umbilical vein endothelial cells (HUVECs). In vitro, dioscin decreased monocyte adhesion to TNF-alpha-treated HUVECs by reducing vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression and inhibiting endothelial lipase (EL) expression in TNF-a-treated HUVECs and macrophages by blocking the nuclear factor-kappa B (NF-kappa B) pathway. Thus, dioscin might inhibit inflammation by interrupting the NF-kappa B signaling pathway and could potentially contribute to treatments for inflammatory diseases and atherosclerosis. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
Language英语
WOS IDWOS:000350920400007
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146113
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Med Univ, Coll Pharm, Dept Clin Pharmacol, Dalian 116044, Liaoning Provin, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Liaoning Provin, Peoples R China
Recommended Citation
GB/T 7714
Wu, Shan,Xu, Hui,Peng, Jinyong,et al. Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway[J]. BIOCHIMIE,2015,110C:62-72.
APA Wu, Shan.,Xu, Hui.,Peng, Jinyong.,Wang, Changyuan.,Jin, Yue.,...&Qin, Jianhua.(2015).Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway.BIOCHIMIE,110C,62-72.
MLA Wu, Shan,et al."Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway".BIOCHIMIE 110C(2015):62-72.
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