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Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway
Wu, Shan1; Xu, Hui2; Peng, Jinyong1; Wang, Changyuan1; Jin, Yue1; Liu, Kexin1; Sun, Huijun1; Qin, Jianhua2
关键词Dioscin Tnf-alpha Nf-kappa b Pathways El Huvecs Monocytes
刊名BIOCHIMIE
2015-03-01
DOI10.1016/j.biochi.2014.12.022
110C页:62-72
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]ENDOTHELIAL-CELL-ADHESION ; ATHEROSCLEROTIC LESION ; LINKING INFLAMMATION ; LIPASE ; ACTIVATION ; ATHEROGENESIS ; MECHANISMS ; MOLECULES ; CYTOKINES ; DISEASES
英文摘要The modulation of adhesion molecule expression and the reduction of aberrant leukocyte adhesion to the endothelium are attractive approaches for treating inflammation-related vascular complications, including atherosclerosis. Dioscin has a variety of biological activities including anti-inflammatory activity. However, the molecular mechanisms behind dioscin's anti-inflammatory effects are not fully understood. In this study, we investigated the molecular mechanism involved in the effects of dioscin on inflammatory mediators in tumor necrosis factor-alpha (TNF-alpha)-stimulated human umbilical vein endothelial cells (HUVECs). In vitro, dioscin decreased monocyte adhesion to TNF-alpha-treated HUVECs by reducing vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression and inhibiting endothelial lipase (EL) expression in TNF-a-treated HUVECs and macrophages by blocking the nuclear factor-kappa B (NF-kappa B) pathway. Thus, dioscin might inhibit inflammation by interrupting the NF-kappa B signaling pathway and could potentially contribute to treatments for inflammatory diseases and atherosclerosis. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
语种英语
WOS记录号WOS:000350920400007
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146113
专题中国科学院大连化学物理研究所
作者单位1.Dalian Med Univ, Coll Pharm, Dept Clin Pharmacol, Dalian 116044, Liaoning Provin, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Liaoning Provin, Peoples R China
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Wu, Shan,Xu, Hui,Peng, Jinyong,et al. Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway[J]. BIOCHIMIE,2015,110C:62-72.
APA Wu, Shan.,Xu, Hui.,Peng, Jinyong.,Wang, Changyuan.,Jin, Yue.,...&Qin, Jianhua.(2015).Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway.BIOCHIMIE,110C,62-72.
MLA Wu, Shan,et al."Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway".BIOCHIMIE 110C(2015):62-72.
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