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题名: Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway
作者: Wu, Shan1;  Xu, Hui2;  Peng, Jinyong1;  Wang, Changyuan1;  Jin, Yue1;  Liu, Kexin1;  Sun, Huijun1;  Qin, Jianhua2
关键词: Dioscin ;  TNF-alpha ;  NF-kappa B pathways ;  EL ;  HUVECs ;  Monocytes
刊名: BIOCHIMIE
发表日期: 2015-03-01
DOI: 10.1016/j.biochi.2014.12.022
卷: 110C, 页:62-72
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: The modulation of adhesion molecule expression and the reduction of aberrant leukocyte adhesion to the endothelium are attractive approaches for treating inflammation-related vascular complications, including atherosclerosis. Dioscin has a variety of biological activities including anti-inflammatory activity. However, the molecular mechanisms behind dioscin's anti-inflammatory effects are not fully understood. In this study, we investigated the molecular mechanism involved in the effects of dioscin on inflammatory mediators in tumor necrosis factor-alpha (TNF-alpha)-stimulated human umbilical vein endothelial cells (HUVECs). In vitro, dioscin decreased monocyte adhesion to TNF-alpha-treated HUVECs by reducing vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression and inhibiting endothelial lipase (EL) expression in TNF-a-treated HUVECs and macrophages by blocking the nuclear factor-kappa B (NF-kappa B) pathway. Thus, dioscin might inhibit inflammation by interrupting the NF-kappa B signaling pathway and could potentially contribute to treatments for inflammatory diseases and atherosclerosis. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
关键词[WOS]: ENDOTHELIAL-CELL-ADHESION ;  ATHEROSCLEROTIC LESION ;  LINKING INFLAMMATION ;  LIPASE ;  ACTIVATION ;  ATHEROGENESIS ;  MECHANISMS ;  MOLECULES ;  CYTOKINES ;  DISEASES
语种: 英语
WOS记录号: WOS:000350920400007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146113
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Med Univ, Coll Pharm, Dept Clin Pharmacol, Dalian 116044, Liaoning Provin, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Liaoning Provin, Peoples R China

Recommended Citation:
Wu, Shan,Xu, Hui,Peng, Jinyong,et al. Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway[J]. BIOCHIMIE,2015,110C:62-72.
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