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Dopant titrating ion mobility spectrometry for trace exhaled nitric oxide detection
Peng, Liying1,3; Hua, Lei1; Li, Enyou2; Wang, Weiguo1; Zhou, Qinghua1,3; Wang, Xin1; Wang, Changsong2; Li, Jinghua1; Li, Haiyang1
KeywordIon Mobility Spectrometry Exhaled Nitric Oxide Breath Gas Dopant
Source PublicationJOURNAL OF BREATH RESEARCH
2015-03-01
DOI10.1088/1752-7155/9/1/016003
Volume9Issue:1
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemical Research Methods ; Respiratory System
WOS Research AreaBiochemistry & Molecular Biology ; Respiratory System
WOS KeywordMASS-SPECTROMETRY ; CORONA DISCHARGE ; BREATH ; AIR ; MIXTURES ; SERIES ; GASES ; MEDIA ; IMS
AbstractIon mobility spectrometry (IMS) is a promising non-invasive tool for the analysis of exhaled gas and exhaled nitric oxide (NO), a biomarker for diagnosis of respiratory diseases. However, the high moisture in exhaled gas always brings about extra overlapping ion peaks and results in poor identification ability. In this paper, p-benzoquinone (PBQ) was introduced into IMS to eliminate the interference of overlapping ion peaks and realize the selective identification of NO. The overlapping ions caused by moisture were titrated by PBQ and then converted to hydrated PBQ anions (C6H4O2-(H2O)(n)). The NO concentration could be determined by quantifying gas phase hydrated nitrite anions (NO2-(H2O)(n)), product ions of NO. Under optimized conditions, a limit of detection (LOD) of about 1.4 ppbv and a linear range of 10-200 ppbv were obtained for NO even in 100% relative humidity (RH) purified air. Furthermore, this established method was applied to measure hourly the exhaled NO of eight healthy volunteers, and real-time monitoring the exhaled NO of an esophageal carcinoma patient during radical surgery. These results revealed the potential of the current dopant titrating IMS method in the measurement of exhaled NO for medical disease diagnosis.
Language英语
WOS IDWOS:000351955400004
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146117
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Harbin Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Peng, Liying,Hua, Lei,Li, Enyou,et al. Dopant titrating ion mobility spectrometry for trace exhaled nitric oxide detection[J]. JOURNAL OF BREATH RESEARCH,2015,9(1).
APA Peng, Liying.,Hua, Lei.,Li, Enyou.,Wang, Weiguo.,Zhou, Qinghua.,...&Li, Haiyang.(2015).Dopant titrating ion mobility spectrometry for trace exhaled nitric oxide detection.JOURNAL OF BREATH RESEARCH,9(1).
MLA Peng, Liying,et al."Dopant titrating ion mobility spectrometry for trace exhaled nitric oxide detection".JOURNAL OF BREATH RESEARCH 9.1(2015).
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