DICP OpenIR
Time-resolved dynamic dilution introduction for ion mobility spectrometry and its application in end-tidal propofol monitoring
Zhou, Qinghua1,3; Li, Enyou2; Wang, Zhenxin1; Gong, Yulei2; Wang, Changsong2; Guo, Lei2; Li, Haiyang1
KeywordTime-resolved Dynamic Dilution Introduction Ion Mobility Spectrometry Propofol
Source PublicationJOURNAL OF BREATH RESEARCH
2015-03-01
DOI10.1088/1752-7155/9/1/016002
Volume9Issue:1
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemical Research Methods ; Respiratory System
WOS Research AreaBiochemistry & Molecular Biology ; Respiratory System
WOS KeywordTOTAL INTRAVENOUS ANESTHESIA ; SENSITIVE DETECTION ; ONLINE MEASUREMENT ; MASS-SPECTROMETRY ; HUMAN BREATH ; EXHALED AIR ; GAS ; EXPLOSIVES ; FEASIBILITY ; METABOLITES
AbstractBased on the adsorption of analytes in the sampling loop, a time-resolved dynamic dilution introduction method was developed for negative ion mobility spectrometry to continuously monitor end-tidal propofol without other sample pre-separation. The dynamic dilution characteristics of propofol and moisture in the Teflon sample loop (4 mm o. d. and 2.4 mm i. d., 150 cm length) were both theoretically and experimentally investigated. The prominent absorption differences between propofol and moisture on the inwall of the sample loop allowed their concentrations to be time-resolved during the injection process, realizing sensitive measurement of end-tidal propofol with a response time of 2 s. At the optimized carrier gas flow rate of 700 mL min(-1), the linear response range for propofol was achieved to be 0.2 to 20 ppbv with a limit of detection (LOD) of 65 pptv. Finally, this method was performed on a patient undergoing mastectomy surgery to continuously monitor the end-tidal propofol with an interval of five respirations and the result nicely demonstrated its fast response to the propofol changes.
Language英语
WOS IDWOS:000351955400003
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146120
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China
2.Harbin Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Qinghua,Li, Enyou,Wang, Zhenxin,et al. Time-resolved dynamic dilution introduction for ion mobility spectrometry and its application in end-tidal propofol monitoring[J]. JOURNAL OF BREATH RESEARCH,2015,9(1).
APA Zhou, Qinghua.,Li, Enyou.,Wang, Zhenxin.,Gong, Yulei.,Wang, Changsong.,...&Li, Haiyang.(2015).Time-resolved dynamic dilution introduction for ion mobility spectrometry and its application in end-tidal propofol monitoring.JOURNAL OF BREATH RESEARCH,9(1).
MLA Zhou, Qinghua,et al."Time-resolved dynamic dilution introduction for ion mobility spectrometry and its application in end-tidal propofol monitoring".JOURNAL OF BREATH RESEARCH 9.1(2015).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhou, Qinghua]'s Articles
[Li, Enyou]'s Articles
[Wang, Zhenxin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhou, Qinghua]'s Articles
[Li, Enyou]'s Articles
[Wang, Zhenxin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhou, Qinghua]'s Articles
[Li, Enyou]'s Articles
[Wang, Zhenxin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.