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题名: Time-resolved dynamic dilution introduction for ion mobility spectrometry and its application in end-tidal propofol monitoring
作者: Zhou, Qinghua1, 3;  Li, Enyou2;  Wang, Zhenxin1;  Gong, Yulei2;  Wang, Changsong2;  Guo, Lei2;  Li, Haiyang1
关键词: time-resolved dynamic dilution introduction ;  ion mobility spectrometry ;  propofol
刊名: JOURNAL OF BREATH RESEARCH
发表日期: 2015-03-01
DOI: 10.1088/1752-7155/9/1/016002
卷: 9, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods ;  Respiratory System
研究领域[WOS]: Biochemistry & Molecular Biology ;  Respiratory System
英文摘要: Based on the adsorption of analytes in the sampling loop, a time-resolved dynamic dilution introduction method was developed for negative ion mobility spectrometry to continuously monitor end-tidal propofol without other sample pre-separation. The dynamic dilution characteristics of propofol and moisture in the Teflon sample loop (4 mm o. d. and 2.4 mm i. d., 150 cm length) were both theoretically and experimentally investigated. The prominent absorption differences between propofol and moisture on the inwall of the sample loop allowed their concentrations to be time-resolved during the injection process, realizing sensitive measurement of end-tidal propofol with a response time of 2 s. At the optimized carrier gas flow rate of 700 mL min(-1), the linear response range for propofol was achieved to be 0.2 to 20 ppbv with a limit of detection (LOD) of 65 pptv. Finally, this method was performed on a patient undergoing mastectomy surgery to continuously monitor the end-tidal propofol with an interval of five respirations and the result nicely demonstrated its fast response to the propofol changes.
关键词[WOS]: TOTAL INTRAVENOUS ANESTHESIA ;  SENSITIVE DETECTION ;  ONLINE MEASUREMENT ;  MASS-SPECTROMETRY ;  HUMAN BREATH ;  EXHALED AIR ;  GAS ;  EXPLOSIVES ;  FEASIBILITY ;  METABOLITES
语种: 英语
WOS记录号: WOS:000351955400003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146120
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China
2.Harbin Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Zhou, Qinghua,Li, Enyou,Wang, Zhenxin,et al. Time-resolved dynamic dilution introduction for ion mobility spectrometry and its application in end-tidal propofol monitoring[J]. JOURNAL OF BREATH RESEARCH,2015,9(1).
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