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Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4
Jiang, Li1; Liang, Si-Cheng2,3; Wang, Chao1; Ge, Guang-Bo2; Huo, Xiao-Kui1; Qi, Xiao-Yi4; Deng, Sa1; Liu, Ke-Xin1; Ma, Xiao-Chi1
刊名SCIENTIFIC REPORTS
2015-04-17
DOI10.1038/srep09627
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]HUMAN UDP-GLUCURONOSYLTRANSFERASES ; HUMAN LIVER-MICROSOMES ; DRUG-GLUCURONIDATION ; N-GLUCURONIDATION ; MASS-SPECTROMETRY ; CHROMATOGRAPHY ; SUBSTRATE ; ACID ; IDENTIFICATION ; AMITRIPTYLINE
英文摘要Glucuronidation mediated by uridine 59-diphospho (UDP)-glucuronosyltransferase is an important detoxification pathway. However, identifying a selective probe of UDP-glucuronosyltransferase is complicated because of the significant overlapping substrate specificity displayed by the enzyme. In this paper, desacetylcinobufagin (DACB) 3-O- and 16-O-glucuronidation were found to be isoform-specific probe reactions for UGT1A4 and UGT1A3, respectively. DACB was well characterized as a probe for simultaneously determining the catalytic activities of O-glucuronidation mediated by UGT1A3 and UGT1A4 from various enzyme sources, through a sensitive analysis method.
语种英语
WOS记录号WOS:000353275700001
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146159
专题中国科学院大连化学物理研究所
作者单位1.Dalian Med Univ, Acad Integrat Med, Coll Pharm, Key Lab Pharmacokinet & Drug Transport Liaoning, Dalian 116044, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
4.Dalian Med Univ, Affiliated Hosp 2, Dalian 116044, Peoples R China
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GB/T 7714
Jiang, Li,Liang, Si-Cheng,Wang, Chao,et al. Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4[J]. SCIENTIFIC REPORTS,2015,5.
APA Jiang, Li.,Liang, Si-Cheng.,Wang, Chao.,Ge, Guang-Bo.,Huo, Xiao-Kui.,...&Ma, Xiao-Chi.(2015).Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4.SCIENTIFIC REPORTS,5.
MLA Jiang, Li,et al."Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4".SCIENTIFIC REPORTS 5(2015).
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