中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Interaction of Metal Ions with the His13-His14 Sequence Relevant to Alzheimer's Disease
作者: Kong, Xiangtao1;  Zhao, Zhi1, 2;  Lei, Xin1;  Zhang, Bingbing1, 3;  Dai, Dongxu1;  Jiang, Ling1
刊名: JOURNAL OF PHYSICAL CHEMISTRY A
发表日期: 2015-04-09
DOI: 10.1021/acs.jpca.5b01443
卷: 119, 期:14, 页:3528-3534
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Physical ;  Physics, Atomic, Molecular & Chemical
研究领域[WOS]: Chemistry ;  Physics
英文摘要: The interaction of a series of metal ions (i.e., groups 1 and 2, first-row transition metals, and groups 11-14) with the His13-His14 sequence relevant to Alzheimer's disease has been studied using quantum chemical calculations. Metal ions prefer to occupy three coordination sites at two N-delta of the imidazole rings and one carbonyl oxygen. Simulated IR spectra reveal that vibrational frequency of C-O stretch affords a sensitive probe for understanding the interaction of His13-His14 with metal ions. The relative strength of the interaction of His13-His14 with the representative metal ions follows the order of K+ < Ca2+ < Zn2+ < Cu2+ < Fe3+ < Al-3+,Al- which is closely correlated with the available experimental results, providing a vivid physical picture about how metal ions bind to amyloid beta-peptide. IR spectra of the [M center dot(His13-His14)](n+) complexes could be measured by infrared photodissociation spectroscopic technique and thus afford useful information for the understanding of structure-function relationship and the design of suitable drugs.
关键词[WOS]: BETA-AMYLOID PEPTIDE ;  SENILE PLAQUE CORES ;  A-BETA ;  GAS-PHASE ;  PHOTODISSOCIATION SPECTROSCOPY ;  INFRARED-SPECTROSCOPY ;  SUPEROXIDE-DISMUTASE ;  NEURONAL DEATH ;  CLUSTER IONS ;  ZINC
语种: 英语
WOS记录号: WOS:000352823100024
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146160
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, iChEM, State Key Lab Mol React Dynam, Dalian 116023, Liaoning, Peoples R China
2.Dalian Univ Technol, Sch Phys & Optoelect Technol, Dalian 116024, Peoples R China
3.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

Recommended Citation:
Kong, Xiangtao,Zhao, Zhi,Lei, Xin,et al. Interaction of Metal Ions with the His13-His14 Sequence Relevant to Alzheimer's Disease[J]. JOURNAL OF PHYSICAL CHEMISTRY A,2015,119(14):3528-3534.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Kong, Xiangtao]'s Articles
 [Zhao, Zhi]'s Articles
 [Lei, Xin]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Kong, Xiangtao]‘s Articles
 [Zhao, Zhi]‘s Articles
 [Lei, Xin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace