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题名: Ginsenoside Rg1 Downregulates the Shear Stress Induced MCP-1 Expression by Inhibiting MAPK Signaling Pathway
作者: He, Jian1, 2, 3, 4;  Li, Yu-Lin4
关键词: HUVECs ;  Mechanical Force (Shear Stress) ;  Ginsenoside Rg1 ;  MCP-1 ;  MAP Kinase
刊名: AMERICAN JOURNAL OF CHINESE MEDICINE
发表日期: 2015
DOI: 10.1142/S0192415X15500202
卷: 43, 期:2, 页:305-317
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Integrative & Complementary Medicine ;  Medicine, General & Internal
研究领域[WOS]: Integrative & Complementary Medicine ;  General & Internal Medicine
英文摘要: Ginsenoside Rg1 has been reported to possess anti-inflammatory activities, but the effects of Rg1 on the shear induced MCP-1 upregulation mechanism on endothelial cells (ECs) remain to be determined. In this study, we show that Rg1 down modulates shear induced pro-inflammatory cytokine MCP-1 gene expression and monocytes adhesion without potential cell toxicity. The negative effects on monocytes adhesion is due to a decrease in MCP-1 protein release. Furthermore, the inhibitory effect of Rg1 on the phosphorylation level of ERK, p38, and JNK mitogen-activated protein kinase (MAPK) induced by shear stress (SS) is similar with that of specific chemical inhibitors for MAPK pathways activation. These results demonstrate that ginsenoside Rg1 inhibits the shear induced inflammation by suppressing the MAPK pathway. This suggests that Rg1 may serve as a novel anti-inflammatory agent for inflammation-induced cardiovascular diseases treatment.
关键词[WOS]: MONOCYTE CHEMOATTRACTANT PROTEIN-1 ;  VASCULAR ENDOTHELIAL-CELLS ;  GENE-EXPRESSION ;  GLUCOCORTICOID-RECEPTOR ;  CHEMOTACTIC PROTEIN-1 ;  IN-VITRO ;  MECHANOTRANSDUCTION ;  INCREASES ;  KINASES ;  GROWTH
语种: 英语
WOS记录号: WOS:000353162200008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146163
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.Univ Calif San Diego, Dept Bioengn, San Diego, CA 92037 USA
3.Univ Calif San Diego, Inst Engn Med, San Diego, CA 92037 USA
4.Jilin Univ, Minist Educ, Norman Bethune Coll Med, Key Lab Pathobiol, Changchun 130021, Jilin, Peoples R China

Recommended Citation:
He, Jian,Li, Yu-Lin. Ginsenoside Rg1 Downregulates the Shear Stress Induced MCP-1 Expression by Inhibiting MAPK Signaling Pathway[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2015,43(2):305-317.
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