中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Alginate-calcium microsphere loaded with thrombin: A new composite biomaterial for hemostatic embolization
作者: Rong, Jing-jing1;  Liang, Ming2;  Xuan, Feng-qi2;  Sun, Jing-yang2;  Zhao, Li-jun2;  Zhen, Hui-zhen3;  Tian, Xiao-xiang2;  Liu, Dan1, 2;  Zhang, Quan-yu1, 2;  Peng, Cheng-fei2;  Yao, Tian-ming2;  Li, Fei2;  Wang, Xiao-zeng2;  Han, Ya-ling2;  Yu, Wei-ting3
关键词: Alginate ;  Thrombin ;  Microsphere ;  Trauma ;  Arterial embolization ;  Hemostasis
刊名: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
发表日期: 2015-04-01
DOI: 10.1016/j.ijbiomac.2014.12.043
卷: 75, 页:479-488
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: To date, transcatheter arterial embolization (TAE) has become a standard treatment to control intracavitary bleeding as an alternative to surgery. Due to excellent biocompatibility and no residual in vivo, biodegradable materials are preferred in TAE. However, gelfoam is the only commercially available biodegradable embolic material used to treat blunt trauma of solid abdominal viscera until now, and controversial on its stability and reliability never stopped in the past five decades. In this study, a new biodegradable macromolecule material (thrombin-loaded alginate-calcium microspheres, TACMs) was prepared using electrostatic droplet techniques and a special method was developed for hemostatic embolization. Thrombin was successfully loaded into microspheres with high encapsulation efficiency and drug loading capacity. A burst release of TACMs was observed at early stage and sustained release later on, with the activity of thrombin preserved well. The strength of TACMs mixed thrombus, which was used as embolic agent, increased in a dose-dependent manner after TACMs were added. In addition, the TACMs were verified to be of no cytotoxicity and systemic toxicity, and biodegradable in vivo. Finally, the results of preliminary applications revealed that the TACMs could serve as an effective and promising embolic material for blunt trauma and hemorrhage of solid abdominal viscera. (C) 2015 Elsevier B.V. All rights reserved.
关键词[WOS]: SPLENIC ARTERY EMBOLIZATION ;  CONTROLLED-RELEASE ;  POSTPARTUM HEMORRHAGE ;  DELIVERY-SYSTEM ;  IN-VIVO ;  INJURY ;  CHITOSAN ;  TRAUMA ;  BIOCOMPATIBILITY ;  COMPLICATIONS
语种: 英语
WOS记录号: WOS:000352332700063
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146177
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Third Mil Med Univ, Chongqing 400038, Peoples R China
2.Shenyang Mil Reg, Dept Cardiol, Gen Hosp, Shenyang 110016, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China

Recommended Citation:
Rong, Jing-jing,Liang, Ming,Xuan, Feng-qi,et al. Alginate-calcium microsphere loaded with thrombin: A new composite biomaterial for hemostatic embolization[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2015,75:479-488.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Rong, Jing-jing]'s Articles
 [Liang, Ming]'s Articles
 [Xuan, Feng-qi]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Rong, Jing-jing]‘s Articles
 [Liang, Ming]‘s Articles
 [Xuan, Feng-qi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace