DICP OpenIR
Alginate-calcium microsphere loaded with thrombin: A new composite biomaterial for hemostatic embolization
Rong, Jing-jing1; Liang, Ming2; Xuan, Feng-qi2; Sun, Jing-yang2; Zhao, Li-jun2; Zhen, Hui-zhen3; Tian, Xiao-xiang2; Liu, Dan1,2; Zhang, Quan-yu1,2; Peng, Cheng-fei2; Yao, Tian-ming2; Li, Fei2; Wang, Xiao-zeng2; Han, Ya-ling2; Yu, Wei-ting3
关键词Alginate Thrombin Microsphere Trauma Arterial Embolization Hemostasis
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2015-04-01
DOI10.1016/j.ijbiomac.2014.12.043
75页:479-488
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]SPLENIC ARTERY EMBOLIZATION ; CONTROLLED-RELEASE ; POSTPARTUM HEMORRHAGE ; DELIVERY-SYSTEM ; IN-VIVO ; INJURY ; CHITOSAN ; TRAUMA ; BIOCOMPATIBILITY ; COMPLICATIONS
英文摘要To date, transcatheter arterial embolization (TAE) has become a standard treatment to control intracavitary bleeding as an alternative to surgery. Due to excellent biocompatibility and no residual in vivo, biodegradable materials are preferred in TAE. However, gelfoam is the only commercially available biodegradable embolic material used to treat blunt trauma of solid abdominal viscera until now, and controversial on its stability and reliability never stopped in the past five decades. In this study, a new biodegradable macromolecule material (thrombin-loaded alginate-calcium microspheres, TACMs) was prepared using electrostatic droplet techniques and a special method was developed for hemostatic embolization. Thrombin was successfully loaded into microspheres with high encapsulation efficiency and drug loading capacity. A burst release of TACMs was observed at early stage and sustained release later on, with the activity of thrombin preserved well. The strength of TACMs mixed thrombus, which was used as embolic agent, increased in a dose-dependent manner after TACMs were added. In addition, the TACMs were verified to be of no cytotoxicity and systemic toxicity, and biodegradable in vivo. Finally, the results of preliminary applications revealed that the TACMs could serve as an effective and promising embolic material for blunt trauma and hemorrhage of solid abdominal viscera. (C) 2015 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000352332700063
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146177
专题中国科学院大连化学物理研究所
作者单位1.Third Mil Med Univ, Chongqing 400038, Peoples R China
2.Shenyang Mil Reg, Dept Cardiol, Gen Hosp, Shenyang 110016, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
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GB/T 7714
Rong, Jing-jing,Liang, Ming,Xuan, Feng-qi,et al. Alginate-calcium microsphere loaded with thrombin: A new composite biomaterial for hemostatic embolization[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2015,75:479-488.
APA Rong, Jing-jing.,Liang, Ming.,Xuan, Feng-qi.,Sun, Jing-yang.,Zhao, Li-jun.,...&Yu, Wei-ting.(2015).Alginate-calcium microsphere loaded with thrombin: A new composite biomaterial for hemostatic embolization.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,75,479-488.
MLA Rong, Jing-jing,et al."Alginate-calcium microsphere loaded with thrombin: A new composite biomaterial for hemostatic embolization".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 75(2015):479-488.
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