中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells
作者: Hou, Zhi-Jie1, 2;  Luo, Xi1, 2;  Zhang, Wei1, 2;  Peng, Fei1, 2;  Cui, Bai1, 2;  Wu, Si-Jin3;  Zheng, Fei-Meng1, 2;  Xu, Jie1, 2;  Xu, Ling-Zhi1, 2;  Long, Zi-Jie4;  Wang, Xue-Ting1, 2;  Li, Guo-Hui5;  Wan, Xian-Yao6;  Yang, Yong-Liang3;  Liu, Quentin1, 2
关键词: flubendazole ;  breast cancer ;  cancer stem-like cell ;  cell cycle ;  tubulin
刊名: ONCOTARGET
发表日期: 2015-03-20
卷: 6, 期:8, 页:6326-6340
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Oncology ;  Cell Biology
研究领域[WOS]: Oncology ;  Cell Biology
英文摘要: Cancer stem-like cell (CS-like cell) is considered to be responsible for recurrence and drug resistance events in breast cancer, which makes it a potential target for novel cancer therapeutic strategy. The FDA approved flubendazole, has been widely used in the treatment of intestinal parasites. Here, we demonstrated a novel effect of flubendazole on breast CS-like cells. Flubendazole inhibited breast cancer cells proliferation in dose-and time-dependent manner and delayed tumor growth in xenograft models by intraperitoneal injection. Importantly, flubendazole reduced CD44(high)/CD24(low) subpopulation and suppressed the formation of mammosphere and the expression of self-renewal related genes including c-myc, oct4, sox2, nanog and cyclinD1. Moreover, we found that flubendazole induced cell differentiation and inhibited cell migration. Consistently, flubendazole reduced mesenchymal markers (beta-catenin, N-cadherin and Vimentin) expression and induced epithelial and differentiation marker (Keratin 18) expression in breast cancer cells. Mechanism study revealed that flubendazole arrested cell cycle at G2/M phase and induced monopolar spindle formation through inhibiting tubulin polymerization. Furthermore, flubendazole enhanced cytotoxic activity of conventional therapeutic drugs fluorouracil and doxorubicin against breast cancer cells. In conclusion, our findings uncovered a remarkable effect of flubendazole on suppressing breast CS-like cells, indicating a novel utilization of flubendazole in breast cancer therapy.
关键词[WOS]: EPITHELIAL-MESENCHYMAL TRANSITION ;  NEOADJUVANT CHEMOTHERAPY ;  DIABETIC-PATIENTS ;  INITIATING CELLS ;  DRUG-RESISTANCE ;  SIDE POPULATION ;  TUMOR-CELLS ;  ALBENDAZOLE ;  EXPRESSION ;  THERAPY
语种: 英语
WOS记录号: WOS:000352793000061
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146190
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Dalian Med Univ, Inst Canc Stem Cell, Dalian, Peoples R China
2.Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510275, Guangdong, Peoples R China
3.Dalian Univ Technol, Ctr Mol Med, Sch Life Sci & Biotechnol, Dalian, Peoples R China
4.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Hematol, Guangzhou 510275, Guangdong, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Lab Mol Modeling & Design, Dalian, Peoples R China
6.Dalian Med Univ, Dept Crit Care Med, Affiliated Hosp 1, Dalian, Peoples R China

Recommended Citation:
Hou, Zhi-Jie,Luo, Xi,Zhang, Wei,et al. Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells[J]. ONCOTARGET,2015,6(8):6326-6340.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Hou, Zhi-Jie]'s Articles
 [Luo, Xi]'s Articles
 [Zhang, Wei]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Hou, Zhi-Jie]‘s Articles
 [Luo, Xi]‘s Articles
 [Zhang, Wei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace