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题名: Development of the Wade equation for the description of elution peak profile by using second-order rate equations for the sorption kinetics
作者: Hao, Weiqiang1, 2;  Di, Bin3;  Chen, Qiang1;  Wang, Junde4;  Yang, Yongbing1;  Yue, Bangyi1
关键词: Nonlinear liquid chromatography ;  Linear chromatography ;  The Wade equation ;  Langmuir kinetics
刊名: CHEMICAL ENGINEERING RESEARCH & DESIGN
发表日期: 2015-04-01
DOI: 10.1016/j.cherd.2015.02.002
卷: 96, 页:15-22
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Engineering, Chemical
研究领域[WOS]: Engineering
英文摘要: The Wade equation can be used to account for the peak profiles that are obtained under linear and nonlinear (Langmuir) chromatographic conditions. This equation is derived from a kinetic model of chromatography in which axial dispersion is ignored and the adsorption and desorption of solute between mobile and stationary phase are accounted for by a second-order and a first-order rate equation respectively. In this work, we extend the Wade equation to the case where two second-order rate equations are used to account for the sorption kinetics. An approach for the simplification of the Wade equation for practical use is also proposed. We demonstrate that the Wade equation can be reduced to the Gaussian equation when the injection amount is small and the interaction between the solute and binding site on the adsorbent surface is not specific. This result is consistent with the solution derived from the linear driving force model in the scope of analytical chromatography. (C) 2015 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
关键词[WOS]: PREPARATIVE LIQUID-CHROMATOGRAPHY ;  AFFINITY-MEMBRANE BIOSEPARATIONS ;  MASS-TRANSFER ;  COLUMN OVERLOAD ;  BAND PROFILES ;  ADSORPTION ;  ENANTIOMERS ;  PERFORMANCE ;  PREDICTION ;  DIFFUSION
语种: 英语
WOS记录号: WOS:000353610100002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146200
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nanjing Univ, High Tech Res Inst, Changzhou 213164, Peoples R China
2.Shanghai Tobacco Grp Co Ltd, Key Lab Cigarette Smoke Res, CNTC, Shanghai 200082, Peoples R China
3.China Pharmaceut Univ, Dept Pharmaceut Anal, Nanjing 210009, Jiangsu, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Hao, Weiqiang,Di, Bin,Chen, Qiang,et al. Development of the Wade equation for the description of elution peak profile by using second-order rate equations for the sorption kinetics[J]. CHEMICAL ENGINEERING RESEARCH & DESIGN,2015,96:15-22.
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