中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis
作者: Frei, Michelle S.1;  Bilyard, Matthew K.1;  Alanine, Thomas A.1;  Galloway, Warren R. J. D.1;  Stokes, Jamie E.1;  Spring, David R.1, 2
关键词: Heterocycles ;  Scaffold ;  Metathesis ;  Libraries ;  Synthetic methodology
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
发表日期: 2015-06-01
DOI: 10.1016/j.bmc.2014.11.037
卷: 23, 期:11, 页:2666-2679
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemistry & Molecular Biology ;  Chemistry, Medicinal ;  Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ;  Pharmacology & Pharmacy ;  Chemistry
英文摘要: Herein, we report on work towards the development of a new strategy for the synthesis of rare and biologically interesting indolizin-5(3H)-ones, which is based around the use of ring-closing metathesis to construct the carbocyclic ring system. This study has provided insights into the general stability of indolizin-5(3H)-ones and their tendency to exist as the tautomeric indolizin-5-ols. Furthermore, this approach has allowed access to other novel structurally related compounds based around unusual 6,5-azabicyclic scaffolds, which are also difficult to generate using typical methods. The azabicyclic compounds synthesized in this study reside in attractive regions of heterocyclic chemical space that are underexploited in current drug and agrochemical discovery efforts. (C) 2014 Elsevier Ltd. All rights reserved.
关键词[WOS]: CAMPTOTHECIN ;  HETEROCYCLES ;  SPACE
语种: 英语
WOS记录号: WOS:000354025700009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146224
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Frei, Michelle S.,Bilyard, Matthew K.,Alanine, Thomas A.,et al. Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2015,23(11):2666-2679.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Frei, Michelle S.]'s Articles
 [Bilyard, Matthew K.]'s Articles
 [Alanine, Thomas A.]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Frei, Michelle S.]‘s Articles
 [Bilyard, Matthew K.]‘s Articles
 [Alanine, Thomas A.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace