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题名: Proteomic profiling of protein corona formed on the surface of nanomaterial
作者: Zhang, Hongyan1, 2;  Wu, Ren'an1
关键词: protein corona ;  nanomaterial ;  proteomics ;  mass spectrometry ;  identification and quantification ;  gel electrophoresis
刊名: SCIENCE CHINA-CHEMISTRY
发表日期: 2015-05-01
DOI: 10.1007/s11426-015-5395-9
卷: 58, 期:5, 页:780-792
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: The formation of protein coronas on nanomaterial will significantly alter the surface properties of nanomaterial in biological systems and subsequently impact biological responses including signaling, cellular uptake, transport, and toxicity etc. It is of critical importance to understand the formation of protein coronas on the surface of nanomaterial. Analytical techniques, especially mass spectrometry-based proteomics methods, are playing a key role for the qualitative and quantitative analyses of protein coronas on nanomaterial. In this review, the proteomic approaches developed for the characterization of protein coronas on various nanomaterials are introduced with the emphasis on the mass spectrometry-based proteomic strategies.
关键词[WOS]: QUANTITATIVE PROTEOMICS ;  MASS-SPECTROMETRY ;  NANOPARTICLE SIZE ;  PLASMA-PROTEINS ;  DRUG-DELIVERY ;  MAGNETIC NANOPARTICLES ;  SILICA NANOPARTICLES ;  ADSORPTION PATTERNS ;  SAMPLE PREPARATION ;  DIGESTION
语种: 英语
WOS记录号: WOS:000354188900005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146226
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Zhang, Hongyan,Wu, Ren'an. Proteomic profiling of protein corona formed on the surface of nanomaterial[J]. SCIENCE CHINA-CHEMISTRY,2015,58(5):780-792.
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