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题名: Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography-Mass Spectrometry
作者: Liu, Xinyu1;  Zheng, Peng2, 3;  Zhao, Xinjie1;  Zhang, Yuqing2, 3;  Hu, Chunxiu1;  Li, Jia1;  Zhao, Jieyu1;  Zhou, Jingjing2, 3;  Xie, Peng2, 3;  Xu, Guowang1
刊名: JOURNAL OF PROTEOME RESEARCH
发表日期: 2015-05-01
DOI: 10.1021/acs.jproteome.5b00144
卷: 14, 期:5, 页:2322-2330
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: Major depressive disorder (MDD) is a debilitating mental disease with a pronounced impact on the quality of life of many people; however, it is still difficult to diagnose MDD accurately. In this study, a nontargeted metabolomics approach based on ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was used to find the differential metabolites in plasma samples from patients with MDD and healthy controls. Furthermore, a validation analysis focusing on the differential metabolites was performed in another batch of samples using a targeted approach based on the dynamic multiple reactions monitoring method. Levels of acyl carnitines, ether lipids, and tryptophan pronouncedly decreased, whereas LPCs, LPEs, and PEs markedly increased in MDD subjects as compared with the healthy controls. Disturbed pathways, mainly located in acyl carnitine metabolism, lipid metabolism, and tryptophan metabolism, were clearly brought to light in MDD subjects. The binary logistic regression result showed that carnitine C10:1, PE-O 36:5, LPE 18:1 sn-2, and tryptophan can be used as a combinational biomarker to distinguish not only moderate but also severe MDD from healthy control with good sensitivity and specificity. Our findings, on one hand, provide critical insight into the pathological mechanism of MDD and, on the other hand, supply a combinational biomarker to aid the diagnosis of MDD in clinical usage.
关键词[WOS]: OXIDATIVE STRESS ;  RAT MODEL ;  PREFRONTAL CORTEX ;  SURROGATE MARKER ;  MOOD DISORDERS ;  MILD STRESS ;  ACETYLCARNITINE ;  METABOLOMICS ;  METABOLISM ;  CARNITINE
语种: 英语
WOS记录号: WOS:000354004700030
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146252
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China
3.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China

Recommended Citation:
Liu, Xinyu,Zheng, Peng,Zhao, Xinjie,et al. Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2015,14(5):2322-2330.
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