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Synergistic H4NI-AcOH Catalyzed Oxidation of the C-sp(3)-H Bonds of Benzylpyridines with Molecular Oxygen
Ren, Lanhui1,2,3; Wang, Lianyue1,2; Lv, Ying1,2; Li, Guosong1,2; Gao, Shuang1,2
Source PublicationORGANIC LETTERS
2015-05-01
DOI10.1021/acs.orglett.5b00602
Volume17Issue:9Pages:2078-2081
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Organic
WOS Research AreaChemistry
WOS KeywordASYMMETRIC HYDROGENATION ; SELECTIVE OXIDATION ; COPPER ; KETONES ; SALTS ; ISOQUINOLINES ; DERIVATIVES ; ALCOHOLS ; ROUTE
AbstractThe oxidation of benzylpyridines forming benzoylpyridines was achieved based on a synergistic H4NI-AcOH catalyst and molecular oxygen in high yield under solvent-free conditions. This is the first nonmetallic catalytic system for this oxidation transformation using molecular oxygen as the oxidant. The catalytic system has a wide scope of substrates and excellent chemoselectivity, and this procedure can also be scaled up. The study of a preliminary reaction mechanism demonstrated that the oxidation of the C-sp(3)-H bonds of benzylpyridines was promoted by the pyridinium salts formed by AcOH and benzylpyridines. The synergistic effect of H4NI-AcOH was also demonstrated by control experiments.
Language英语
WOS IDWOS:000354004400011
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146258
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Ren, Lanhui,Wang, Lianyue,Lv, Ying,et al. Synergistic H4NI-AcOH Catalyzed Oxidation of the C-sp(3)-H Bonds of Benzylpyridines with Molecular Oxygen[J]. ORGANIC LETTERS,2015,17(9):2078-2081.
APA Ren, Lanhui,Wang, Lianyue,Lv, Ying,Li, Guosong,&Gao, Shuang.(2015).Synergistic H4NI-AcOH Catalyzed Oxidation of the C-sp(3)-H Bonds of Benzylpyridines with Molecular Oxygen.ORGANIC LETTERS,17(9),2078-2081.
MLA Ren, Lanhui,et al."Synergistic H4NI-AcOH Catalyzed Oxidation of the C-sp(3)-H Bonds of Benzylpyridines with Molecular Oxygen".ORGANIC LETTERS 17.9(2015):2078-2081.
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