DICP OpenIR
Pd-catalyzed asymmetric hydrogenation of fluorinated aromatic pyrazol-5-ols via capture of active tautomers
Chen, Zhang-Pei1; Chen, Mu-Wang1; Shi, Lei1; Yu, Chang-Bin1; Zhou, Yong-Gui1,2
Source PublicationCHEMICAL SCIENCE
2015
DOI10.1039/c5sc00835b
Volume6Issue:6Pages:3415-3419
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordHIGHLY ENANTIOSELECTIVE HYDROGENATION ; HETEROAROMATIC-COMPOUNDS ; PYRIDINIUM SALTS ; PERFLUOROALKYLATION REACTIONS ; ISOQUINOLINIUM SALTS ; ANTIBACTERIAL AGENTS ; KINETIC RESOLUTION ; AZOMETHINE IMINES ; BRONSTED ACIDS ; QUINOLINES
AbstractAn efficient palladium-catalyzed asymmetric hydrogenation of fluorinated aromatic pyrazol-5-ols has been developed via capture of the active tautomers. A wide variety of 2,5-disubstituted and 2,4,5-trisubstituted pyrazolidinones have been synthesized with up to 96% and 95% ee, respectively. The hydrogenation pathway includes Bronsted acid promoted tautomerization of pyrazol-5-ols and Pd-catalyzed asymmetric hydrogenation of the active tautomer.
Language英语
WOS IDWOS:000354815600018
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146260
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
Recommended Citation
GB/T 7714
Chen, Zhang-Pei,Chen, Mu-Wang,Shi, Lei,et al. Pd-catalyzed asymmetric hydrogenation of fluorinated aromatic pyrazol-5-ols via capture of active tautomers[J]. CHEMICAL SCIENCE,2015,6(6):3415-3419.
APA Chen, Zhang-Pei,Chen, Mu-Wang,Shi, Lei,Yu, Chang-Bin,&Zhou, Yong-Gui.(2015).Pd-catalyzed asymmetric hydrogenation of fluorinated aromatic pyrazol-5-ols via capture of active tautomers.CHEMICAL SCIENCE,6(6),3415-3419.
MLA Chen, Zhang-Pei,et al."Pd-catalyzed asymmetric hydrogenation of fluorinated aromatic pyrazol-5-ols via capture of active tautomers".CHEMICAL SCIENCE 6.6(2015):3415-3419.
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