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题名: The relationship between the inflammatory response and cell adhesion on alginate-chitosan-alginate microcapsules after transplantation
作者: Li, Shen1, 2;  Zhang, Ying2;  Chen, Li2, 3;  Li, Na2, 3;  Xie, Hongguo2;  Guo, Xin2;  Zhao, Shan2;  Yu, Weiting2;  Lv, Yan2;  Lv, Guojun2;  Wu, Huijian1, 4;  Ma, Xiaojun2
关键词: microcapsule ;  transplantation ;  cell adhesion ;  peritoneal cavity ;  inflammatory response
刊名: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
发表日期: 2015-07-01
DOI: 10.1002/jbm.a.35369
卷: 103, 期:7, 页:2333-2343
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Engineering, Biomedical ;  Materials Science, Biomaterials
研究领域[WOS]: Engineering ;  Materials Science
英文摘要: Cell microencapsulation technology is a potential alternative therapy, but cell overgrowth and adhesion on the microcapsules after transplantation shortens their time of therapeutic efficacy. Inflammatory cells were the main cells that adhered to the microcapsules, so understanding the body's inflammatory processes would help to better identify the mechanisms of cell adhesion to the outer surface of the microcapsules. Our study measured the inflammatory cells and the cytokines and characterized the associated changes in the alginate-chitosan-alginate (ACA) microcapsules 1, 7, 14, and 28 days after implantation in the peritoneal cavity. Then the relationship between the inflammatory response and cell adhesion on the microcapsules was evaluated by multiple regression analysis. The results showed that the microcapsules did not evoke a systemic inflammatory response, but initiated a local inflammatory response in the peritoneal cavity. Furthermore, the correlation analysis showed that the level of cell adhesion on the microcapsules was related to the number of lymphocytes and macrophages, and the amount of IL-6, IL-10, and MCP-1 in the peritoneal cavity. Our results may provide a foundation for reducing the immune response to these microcapsules, prolonging graft survival and improving the efficacy of these treatments. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103: 2333-2343, 2015.
关键词[WOS]: MESENCHYMAL STEM-CELLS ;  ISLETS ;  TISSUE ;  DELIVERY ;  BIOCOMPATIBILITY ;  ACTIVATION ;  REJECTION ;  STEROIDS ;  RELEASE ;  MODEL
语种: 英语
WOS记录号: WOS:000355246400013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146273
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Dalian Univ Technol, Sch Life Sci & Med, Panjin, Peoples R China

Recommended Citation:
Li, Shen,Zhang, Ying,Chen, Li,et al. The relationship between the inflammatory response and cell adhesion on alginate-chitosan-alginate microcapsules after transplantation[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2015,103(7):2333-2343.
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