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题名: Ultrasmall single micelle@resin core-shell nanocarriers as efficient cargo loading vehicles for in vivo biomedical applications
作者: Yang, Yan1;  Song, Xiaojie2;  Yao, Yi1;  Wu, Hao2;  Liu, Jian1;  Zhao, Yaopeng1;  Tan, Mingqian2;  Yang, Qihua1
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2015
DOI: 10.1039/c5tb00398a
卷: 3, 期:23, 页:4671-4678
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
英文摘要: Ultrasmall core-shell nanocarriers (NCs) are believed to be ideal candidates for biological applications, as proved by silica-based core-shell NCs fabricated using a single micelle as a template. Compared with inert silica, polymers with various properties play an essential and ubiquitous role in our daily life. However, the fabrication of polymer-based NCs with ultrasmall particle size (less than 20 nm) is still very limited, which is probably hindered due to the difficulty in handling the polymeric process and the soft nature of most polymers. In this study, we demonstrated the fabrication of ultrasmall single micelle@resin core-shell NCs through a single micelle template method using resorcinol-formaldehyde resins (RFRs) as model polymers. Moreover, the fluorescence properties of the ultrasmall single micelle@resin core-shell NCs could be adjusted from visible light to near-infrared through the incorporation of different dye molecules. The fluorescent single micelle@RFR core-shell NCs show extra-low cytotoxicity and great potential in both in vitro and in vivo bioimaging and photothermal therapy applications.
关键词[WOS]: QUANTUM DOTS ;  HYDROTHERMAL SYNTHESIS ;  FORMALDEHYDE POLYMER ;  CARBON NANOSPHERES ;  BLOCK-COPOLYMERS ;  STOBER METHOD ;  SILICA ;  NANOPARTICLES ;  SPHERES ;  FABRICATION
语种: 英语
WOS记录号: WOS:000355737600006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146292
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China

Recommended Citation:
Yang, Yan,Song, Xiaojie,Yao, Yi,et al. Ultrasmall single micelle@resin core-shell nanocarriers as efficient cargo loading vehicles for in vivo biomedical applications[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(23):4671-4678.
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