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Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha
Sum, Tze Han1; Sum, Tze Jing1; Stokes, Jamie E.1; Galloway, Warren R. J. D.1; Spring, David R.1,2
关键词Natural Product Synthesis Flavonoids Dihydrochalcones Deoxyflavones Divergent Synthesis
刊名TETRAHEDRON
2015-07-01
DOI10.1016/j.tet.2015.02.017
71期:26-27页:4557-4564
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]DIVERSITY-ORIENTED SYNTHESIS ; INHIBITORS ; STRATEGY ; FLAVONOIDS ; CHALCONES ; ALKALOIDS ; QUINONES
英文摘要Dihydrochalcones and 5-deoxyflavones are types of compounds possessing various biologically interesting properties. Herein, we report the concise and divergent total syntheses of several naturally occurring dihydrochalcones and 5-deoxyflavones from readily available starting materials. The divergent strategy is based around manipulation of a common chalcone scaffold and features application of Algar Flynn-Oyamada oxidation and benzoquinone C-H activation methodologies. These are the first reported total syntheses of these biologically interesting compounds and the concise and flexible route should be readily amenable to future analogue generation. Furthermore, this work provides an illustration of the utility of divergent synthesis for the expedient and step-economical preparation of natural product libraries. (C) 2015 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000356207700023
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146311
专题中国科学院大连化学物理研究所
作者单位1.Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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GB/T 7714
Sum, Tze Han,Sum, Tze Jing,Stokes, Jamie E.,et al. Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha[J]. TETRAHEDRON,2015,71(26-27):4557-4564.
APA Sum, Tze Han,Sum, Tze Jing,Stokes, Jamie E.,Galloway, Warren R. J. D.,&Spring, David R..(2015).Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha.TETRAHEDRON,71(26-27),4557-4564.
MLA Sum, Tze Han,et al."Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha".TETRAHEDRON 71.26-27(2015):4557-4564.
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