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题名: Comprehensive lipid profiling of plasma in patients with benign breast tumor and breast cancer reveals novel biomarkers
作者: Yang, Li1;  Cui, Xinge1, 2, 3;  Zhang, Ningning4, 5;  Li, Min1;  Bai, Yu1;  Han, Xiaohong4, 5;  Shi, Yuankai4, 5;  Liu, Huwei1
关键词: Breast cancer ;  Benign breast tumor ;  Lipidomics ;  Biomarker ;  NP/RP 2DLC-MS
刊名: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
发表日期: 2015-07-01
DOI: 10.1007/s00216-015-8484-x
卷: 407, 期:17, 页:5065-5077
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Abnormal lipid metabolism is a common feature in most solid tumors, and occurs in early stages of the tumor progression. As benign breast tumor is different from malignant tumor of breast cancer, it is particularly important to take benign breast tumor into consideration when investigating cancer biomarkers. In this study, by using a normal-phase/reversed-phase two-dimensional liquid chromatography-mass spectrometry (NP/RP 2D LC-MS) method, we conducted comprehensive lipid profiling in human plasma obtained from six benign breast tumor patients and five breast cancer patients, as well as nine healthy controls. As a result, 512 lipid species were successfully identified. Principal component analysis allowed clear separation of the three groups. Quantitative analysis revealed that many lipid contents were similar in benign and malignant breast tumors compared with controls, and these were proposed as potential breast tumor biomarkers other than breast cancer biomarkers. Two phosphatidylinositol (PI) species, including PI (16:0/16:1) and PI (18:0/20:4), could differentiate between benign and malignant breast tumors, as well as breast cancer patients and healthy controls, indicating that they could be utilized as potential breast cancer biomarkers. In addition, PI (16:0/18:1), phosphatidylglycerol (36:3), and glucosylceramide (d18:1/15:1) were demonstrated to be potential biomarkers to evaluate the level of malignancy of breast tumor. Taken together, our results indicate the usefulness of lipid profiling in the discrimination between patients with breast cancer and non-carcinoma lesions, which might provide assistance in clinical diagnosis.
关键词[WOS]: PROTEIN-KINASE-C ;  LC-QTOF-MS ;  MASS-SPECTROMETRY ;  GLUCOSYLCERAMIDE SYNTHASE ;  QUANTITATIVE-ANALYSIS ;  CELLS ;  METABOLISM ;  RESISTANCE ;  CERAMIDE ;  PHOSPHOLIPIDS
语种: 英语
WOS记录号: WOS:000356461800017
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146323
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Inst Analyt Chem,Coll Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China
2.Beijing Union Med Coll Hosp, Clin Pharmacol Res Ctr, Beijing 100730, Peoples R China
3.Chinese Acad Med Sci, Beijing 100730, Peoples R China
4.Peking Union Med Coll, Canc Inst & Hosp, Dept Med Oncol, Beijing 100021, Peoples R China
5.Chinese Acad Med Sci, Beijing 100021, Peoples R China

Recommended Citation:
Yang, Li,Cui, Xinge,Zhang, Ningning,et al. Comprehensive lipid profiling of plasma in patients with benign breast tumor and breast cancer reveals novel biomarkers[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2015,407(17):5065-5077.
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