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题名: CancerHSP: anticancer herbs database of systems pharmacology
作者: Tao, Weiyang1;  Li, Bohui1;  Gao, Shuo1;  Bai, Yaofei1;  Shar, Piar Ali1;  Zhang, Wenjuan1;  Guo, Zihu1;  Sun, Ke1;  Fu, Yingxue1;  Huang, Chao1;  Zheng, Chunli1;  Mu, Jiexin1;  Pei, Tianli1;  Wang, Yuan1;  Li, Yan3;  Wang, Yonghua1, 2
刊名: SCIENTIFIC REPORTS
发表日期: 2015-06-15
DOI: 10.1038/srep11481
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: The numerous natural products and their bioactivity potentially afford an extraordinary resource for new drug discovery and have been employed in cancer treatment. However, the underlying pharmacological mechanisms of most natural anticancer compounds remain elusive, which has become one of the major obstacles in developing novel effective anticancer agents. Here, to address these unmet needs, we developed an anticancer herbs database of systems pharmacology (CancerHSP), which records anticancer herbs related information through manual curation. Currently, CancerHSP contains 2439 anticancer herbal medicines with 3575 anticancer ingredients. For each ingredient, the molecular structure and nine key ADME parameters are provided. Moreover, we also provide the anticancer activities of these compounds based on 492 different cancer cell lines. Further, the protein targets of the compounds are predicted by state-of-art methods or collected from literatures. CancerHSP will help reveal the molecular mechanisms of natural anticancer products and accelerate anticancer drug development, especially facilitate future investigations on drug repositioning and drug discovery. CancerHSP is freely available on the web at http://lsp.nwsuaf.edu.cn/CancerHSP.php.
关键词[WOS]: DRUG-RESISTANCE ;  PREDICTION ;  DISCOVERY ;  RESOURCE
语种: 英语
WOS记录号: WOS:000356506400001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146325
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Northwest A&F Univ, Coll Life Sci, Ctr Bioinformat, Yangling 712100, Shaanxi, Peoples R China
2.Shihezi Univ, Key Lab Xinjiang Endem Phytomed Resources, Sch Pharm, Minist Educ, Shihezi 832002, Xinjiang, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Liaoning, Peoples R China

Recommended Citation:
Tao, Weiyang,Li, Bohui,Gao, Shuo,et al. CancerHSP: anticancer herbs database of systems pharmacology[J]. SCIENTIFIC REPORTS,2015,5.
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