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题名: Fluorescence imaging of metal ions implicated in diseases
作者: Qian, Xuhong1;  Xu, Zhaochao2
刊名: CHEMICAL SOCIETY REVIEWS
发表日期: 2015
DOI: 10.1039/c4cs00292j
卷: 44, 期:14, 页:4487-4493
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Metal ions play an important role in various biological processes, their abnormal homeostasis in cells is related to many diseases, such as neurodegenerative disease, cancer and diabetes. Fluorescent imaging offers a unique route to detect metal ions in cells via a contactless and damage-free way with high spatial and temporal fidelity. Consequently, it represents a promising method to advance the understanding of physiological and pathological functions of metal ions in cell biology. In this highlight article, we will discuss recent advances in fluorescent imaging of metal ions by small-molecule sensors for understanding the role of metals in related diseases. We will also discuss challenges and opportunities for the design of small-molecule sensors for fluorescent detection of cellular metal ions as a potential method for disease diagnosis.
关键词[WOS]: LIVING CELLS ;  OXIDATIVE STRESS ;  AQUEOUS-SOLUTION ;  ZINC ION ;  HIPPOCAMPAL SLICES ;  LIVE CELLS ;  SENSOR ;  ZN2+ ;  PROBE ;  INDICATOR
语种: 英语
WOS记录号: WOS:000357691200002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146381
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem CAS, Dalian 116023, Peoples R China

Recommended Citation:
Qian, Xuhong,Xu, Zhaochao. Fluorescence imaging of metal ions implicated in diseases[J]. CHEMICAL SOCIETY REVIEWS,2015,44(14):4487-4493.
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