DICP OpenIR
Fluorescence imaging of metal ions implicated in diseases
Qian, Xuhong1; Xu, Zhaochao2
刊名CHEMICAL SOCIETY REVIEWS
2015
DOI10.1039/c4cs00292j
44期:14页:4487-4493
收录类别SCI
文章类型Review
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]LIVING CELLS ; OXIDATIVE STRESS ; AQUEOUS-SOLUTION ; ZINC ION ; HIPPOCAMPAL SLICES ; LIVE CELLS ; SENSOR ; ZN2+ ; PROBE ; INDICATOR
英文摘要Metal ions play an important role in various biological processes, their abnormal homeostasis in cells is related to many diseases, such as neurodegenerative disease, cancer and diabetes. Fluorescent imaging offers a unique route to detect metal ions in cells via a contactless and damage-free way with high spatial and temporal fidelity. Consequently, it represents a promising method to advance the understanding of physiological and pathological functions of metal ions in cell biology. In this highlight article, we will discuss recent advances in fluorescent imaging of metal ions by small-molecule sensors for understanding the role of metals in related diseases. We will also discuss challenges and opportunities for the design of small-molecule sensors for fluorescent detection of cellular metal ions as a potential method for disease diagnosis.
语种英语
WOS记录号WOS:000357691200002
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146381
专题中国科学院大连化学物理研究所
作者单位1.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem CAS, Dalian 116023, Peoples R China
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Qian, Xuhong,Xu, Zhaochao. Fluorescence imaging of metal ions implicated in diseases[J]. CHEMICAL SOCIETY REVIEWS,2015,44(14):4487-4493.
APA Qian, Xuhong,&Xu, Zhaochao.(2015).Fluorescence imaging of metal ions implicated in diseases.CHEMICAL SOCIETY REVIEWS,44(14),4487-4493.
MLA Qian, Xuhong,et al."Fluorescence imaging of metal ions implicated in diseases".CHEMICAL SOCIETY REVIEWS 44.14(2015):4487-4493.
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