DICP OpenIR
Fluorescence imaging of metal ions implicated in diseases
Qian, Xuhong1; Xu, Zhaochao2
Source PublicationCHEMICAL SOCIETY REVIEWS
2015
DOI10.1039/c4cs00292j
Volume44Issue:14Pages:4487-4493
Indexed BySCI
SubtypeReview
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordLIVING CELLS ; OXIDATIVE STRESS ; AQUEOUS-SOLUTION ; ZINC ION ; HIPPOCAMPAL SLICES ; LIVE CELLS ; SENSOR ; ZN2+ ; PROBE ; INDICATOR
AbstractMetal ions play an important role in various biological processes, their abnormal homeostasis in cells is related to many diseases, such as neurodegenerative disease, cancer and diabetes. Fluorescent imaging offers a unique route to detect metal ions in cells via a contactless and damage-free way with high spatial and temporal fidelity. Consequently, it represents a promising method to advance the understanding of physiological and pathological functions of metal ions in cell biology. In this highlight article, we will discuss recent advances in fluorescent imaging of metal ions by small-molecule sensors for understanding the role of metals in related diseases. We will also discuss challenges and opportunities for the design of small-molecule sensors for fluorescent detection of cellular metal ions as a potential method for disease diagnosis.
Language英语
WOS IDWOS:000357691200002
Citation statistics
Cited Times:136[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146381
Collection中国科学院大连化学物理研究所
Affiliation1.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem CAS, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Qian, Xuhong,Xu, Zhaochao. Fluorescence imaging of metal ions implicated in diseases[J]. CHEMICAL SOCIETY REVIEWS,2015,44(14):4487-4493.
APA Qian, Xuhong,&Xu, Zhaochao.(2015).Fluorescence imaging of metal ions implicated in diseases.CHEMICAL SOCIETY REVIEWS,44(14),4487-4493.
MLA Qian, Xuhong,et al."Fluorescence imaging of metal ions implicated in diseases".CHEMICAL SOCIETY REVIEWS 44.14(2015):4487-4493.
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