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题名: Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice
作者: Song, Xiaojie1, 2;  Wu, Hao1, 2;  Li, Shen1, 2;  Wang, Yanfang1, 2;  Ma, Xiaojun1;  Tan, Mingqian1
刊名: BIOMACROMOLECULES
发表日期: 2015-07-01
DOI: 10.1021/acs.biomac.5b00511
卷: 16, 期:7, 页:2080-2090
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemistry & Molecular Biology ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Polymer Science
英文摘要: Nanocarriers play an important role in improving the photo- and thermal-stability of photosensitizers to gain better pharmacokinetics behavior in tumor photothermal therapy. Herein, PEGylated chitosan (CG-PEG; PEG: polyethylene glycol) nanoparticles with ultrasmall size (similar to 5 nm), were prepared through a water-in-oil reverse microemulsion method using genipin as a cross-linker. Particle size and zeta-potential can be tuned by varying the molar ratio between chitosan amino groups and genipin. CG-PEG-ICG (ICG: indocyanine green) nanoparticles were fabricated by adding ICG to CG-PEG aqueous solution through a self-assembly method via electrostatic interaction. The resultant CG-PEG-ICG nanoparticles exhibited improved photo- and thermal-stability, good biocompatibility, and low toxicity. When irradiated with a laser, the cells incubated with CG-PEG-ICG nanoparticles showed very low cell viability (15%), indicating the CG-PEG-ICG nanoparticles possess high in vitro photothermal toxicity. Moreover, the CG-PEG nanocarriers can significantly alter the biodistribution and prolong the retention time of ICG in the mice body after intravenous injection. In vivo photothermal study of tumors injected with CG-PEG-ICG nanoparticles containing ICG at a concentration greater than 100 mu g.mL(-1) (100 mu L) induced irreversible tissue damage. The growth of U87 tumors was dramatically inhibited by CG-PEG-ICG nanoparticles, demonstrating that the CG-PEG nanoparticles may act as potential ICG nanocarriers for effective in vivo tumor photothermal therapy.
关键词[WOS]: INDOCYANINE-GREEN ;  SILICA NANOPARTICLES ;  DRUG-DELIVERY ;  IN-VITRO ;  PEG ;  BIODISTRIBUTION ;  HYDROGELS ;  RELEASE ;  SYSTEM
语种: 英语
WOS记录号: WOS:000358026400020
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146390
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Song, Xiaojie,Wu, Hao,Li, Shen,et al. Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice[J]. BIOMACROMOLECULES,2015,16(7):2080-2090.
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