DICP OpenIR
Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice
Song, Xiaojie1,2; Wu, Hao1,2; Li, Shen1,2; Wang, Yanfang1,2; Ma, Xiaojun1; Tan, Mingqian1
Source PublicationBIOMACROMOLECULES
2015-07-01
DOI10.1021/acs.biomac.5b00511
Volume16Issue:7Pages:2080-2090
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS KeywordINDOCYANINE-GREEN ; SILICA NANOPARTICLES ; DRUG-DELIVERY ; IN-VITRO ; PEG ; BIODISTRIBUTION ; HYDROGELS ; RELEASE ; SYSTEM
AbstractNanocarriers play an important role in improving the photo- and thermal-stability of photosensitizers to gain better pharmacokinetics behavior in tumor photothermal therapy. Herein, PEGylated chitosan (CG-PEG; PEG: polyethylene glycol) nanoparticles with ultrasmall size (similar to 5 nm), were prepared through a water-in-oil reverse microemulsion method using genipin as a cross-linker. Particle size and zeta-potential can be tuned by varying the molar ratio between chitosan amino groups and genipin. CG-PEG-ICG (ICG: indocyanine green) nanoparticles were fabricated by adding ICG to CG-PEG aqueous solution through a self-assembly method via electrostatic interaction. The resultant CG-PEG-ICG nanoparticles exhibited improved photo- and thermal-stability, good biocompatibility, and low toxicity. When irradiated with a laser, the cells incubated with CG-PEG-ICG nanoparticles showed very low cell viability (15%), indicating the CG-PEG-ICG nanoparticles possess high in vitro photothermal toxicity. Moreover, the CG-PEG nanocarriers can significantly alter the biodistribution and prolong the retention time of ICG in the mice body after intravenous injection. In vivo photothermal study of tumors injected with CG-PEG-ICG nanoparticles containing ICG at a concentration greater than 100 mu g.mL(-1) (100 mu L) induced irreversible tissue damage. The growth of U87 tumors was dramatically inhibited by CG-PEG-ICG nanoparticles, demonstrating that the CG-PEG nanoparticles may act as potential ICG nanocarriers for effective in vivo tumor photothermal therapy.
Language英语
WOS IDWOS:000358026400020
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146390
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Song, Xiaojie,Wu, Hao,Li, Shen,et al. Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice[J]. BIOMACROMOLECULES,2015,16(7):2080-2090.
APA Song, Xiaojie,Wu, Hao,Li, Shen,Wang, Yanfang,Ma, Xiaojun,&Tan, Mingqian.(2015).Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice.BIOMACROMOLECULES,16(7),2080-2090.
MLA Song, Xiaojie,et al."Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice".BIOMACROMOLECULES 16.7(2015):2080-2090.
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