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题名: Synthesis of a hydrophilic maltose functionalized Au NP/PDA/Fe3O4-RGO magnetic nanocomposite for the highly specific enrichment of glycopeptides
作者: Bi, Changfen1, 2;  Jiang, Ruidong1, 2;  He, Xiwen1, 2;  Chen, Langxing1, 2;  Zhang, Yukui1, 2, 3
刊名: RSC ADVANCES
发表日期: 2015
DOI: 10.1039/c5ra06911d
卷: 5, 期:73, 页:59408-59416
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: The development of methods to isolate and enrich low-abundance glycopeptides is an important prerequisite for glycoproteomics research. In this study, a hydrophilic maltose functionalized Au nanoparticle (NP)/polydopamine (PDA)/Fe3O4-reduced graphene oxide (RGO) nanocomposite has been successfully synthesized in mild conditions. The bioadhesive polydopamine film was prepared by self-polymerization on the surface of Fe3O4-graphene oxide, which not only prevents the agglomeration of the graphene sheets and enhances the specific surface area, but also facilitates the Au NP immobilization. A great number of loading Au NPs possess the highly available surface area for the immobilization of the high density of the thiol-terminated maltose via Au-S bonds. The resulting Au NP-maltose/PDA/Fe3O4-RGO nanocomposite exhibits excellent environmental stability, good biocompatibility and water dispersibility. Furthermore, the highly loaded Fe3O4 NPs make the enrichment very convenient. With all of these advances, the novel Au NP-maltose/PDA/Fe3O4-RGO nanocomposite presents selective enrichment of the glycopeptides from a low concentration of horseradish peroxidase tryptic digest (0.1 ng mu L-1).
关键词[WOS]: INTERACTION LIQUID-CHROMATOGRAPHY ;  SELECTIVE ENRICHMENT ;  AFFINITY-CHROMATOGRAPHY ;  FACILE PREPARATION ;  MASS-SPECTROMETRY ;  CLICK MALTOSE ;  NANOPARTICLES ;  GRAPHENE ;  GLYCOSYLATION ;  PHASE
语种: 英语
WOS记录号: WOS:000357961800056
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146395
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, Coll Chem, Res Ctr Analyt Sci,State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Bi, Changfen,Jiang, Ruidong,He, Xiwen,et al. Synthesis of a hydrophilic maltose functionalized Au NP/PDA/Fe3O4-RGO magnetic nanocomposite for the highly specific enrichment of glycopeptides[J]. RSC ADVANCES,2015,5(73):59408-59416.
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