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Synthesis of a hydrophilic maltose functionalized Au NP/PDA/Fe3O4-RGO magnetic nanocomposite for the highly specific enrichment of glycopeptides
Bi, Changfen1,2; Jiang, Ruidong1,2; He, Xiwen1,2; Chen, Langxing1,2; Zhang, Yukui1,2,3
Source PublicationRSC ADVANCES
2015
DOI10.1039/c5ra06911d
Volume5Issue:73Pages:59408-59416
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordINTERACTION LIQUID-CHROMATOGRAPHY ; SELECTIVE ENRICHMENT ; AFFINITY-CHROMATOGRAPHY ; FACILE PREPARATION ; MASS-SPECTROMETRY ; CLICK MALTOSE ; NANOPARTICLES ; GRAPHENE ; GLYCOSYLATION ; PHASE
AbstractThe development of methods to isolate and enrich low-abundance glycopeptides is an important prerequisite for glycoproteomics research. In this study, a hydrophilic maltose functionalized Au nanoparticle (NP)/polydopamine (PDA)/Fe3O4-reduced graphene oxide (RGO) nanocomposite has been successfully synthesized in mild conditions. The bioadhesive polydopamine film was prepared by self-polymerization on the surface of Fe3O4-graphene oxide, which not only prevents the agglomeration of the graphene sheets and enhances the specific surface area, but also facilitates the Au NP immobilization. A great number of loading Au NPs possess the highly available surface area for the immobilization of the high density of the thiol-terminated maltose via Au-S bonds. The resulting Au NP-maltose/PDA/Fe3O4-RGO nanocomposite exhibits excellent environmental stability, good biocompatibility and water dispersibility. Furthermore, the highly loaded Fe3O4 NPs make the enrichment very convenient. With all of these advances, the novel Au NP-maltose/PDA/Fe3O4-RGO nanocomposite presents selective enrichment of the glycopeptides from a low concentration of horseradish peroxidase tryptic digest (0.1 ng mu L-1).
Language英语
WOS IDWOS:000357961800056
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146395
Collection中国科学院大连化学物理研究所
Affiliation1.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, Coll Chem, Res Ctr Analyt Sci,State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Bi, Changfen,Jiang, Ruidong,He, Xiwen,et al. Synthesis of a hydrophilic maltose functionalized Au NP/PDA/Fe3O4-RGO magnetic nanocomposite for the highly specific enrichment of glycopeptides[J]. RSC ADVANCES,2015,5(73):59408-59416.
APA Bi, Changfen,Jiang, Ruidong,He, Xiwen,Chen, Langxing,&Zhang, Yukui.(2015).Synthesis of a hydrophilic maltose functionalized Au NP/PDA/Fe3O4-RGO magnetic nanocomposite for the highly specific enrichment of glycopeptides.RSC ADVANCES,5(73),59408-59416.
MLA Bi, Changfen,et al."Synthesis of a hydrophilic maltose functionalized Au NP/PDA/Fe3O4-RGO magnetic nanocomposite for the highly specific enrichment of glycopeptides".RSC ADVANCES 5.73(2015):59408-59416.
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