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Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells
Xia, Zhengxiang1,2; Zhang, Hong1,2; Xu, Danqing1,2; Lao, Yuanzhi1,2; Fu, Wenwei1,2; Tan, Hongsheng1,2; Cao, Peng3; Yang, Ling4; Xu, Hongxi1,2
关键词Garcinia Cowa Xanthone Cytotoxicity Apoptosis Cell Cycle Arrest Autophagy
刊名MOLECULES
2015-06-01
DOI10.3390/molecules200611387
20期:6页:11387-11399
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]POLYPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES ; PRENYLATED XANTHONES ; MANGOSTANA ; TWIGS ; BENZOPHENONE ; CONSTITUENTS ; METABOLISM ; BARK
英文摘要Two new xanthones, cowaxanthones G (1) and H (2), and 23 known analogues were isolated from an acetone extract of the leaves of Garcinia cowa. The isolated compounds were evaluated for cytotoxicity against three cancer cell lines and immortalized HL7702 normal liver cells, whereby compounds 1, 5, 8, and 15-17 exhibited significant cytotoxicity. Cell cycle analysis using flow cytometry showed that 5 induced cell cycle arrest at the S phase in a dose-dependent manner, 1 and 16 at the G2/M phase, and 17 at the G1 phase, while 16 and 17 induced apoptosis. Moreover, autophagy analysis by GFP-LC3 puncta formation and western blotting suggested that 17 induced autophagy. Taken together, our results suggest that these xanthones possess anticancer activities targeting cell cycle, apoptosis, and autophagy signaling pathways.
语种英语
WOS记录号WOS:000357992700115
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146402
专题中国科学院大连化学物理研究所
作者单位1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
2.Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China
3.Jiangsu Prov Acad Tradit Chinese Med, Nanjing 210028, Jiangsu, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
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Xia, Zhengxiang,Zhang, Hong,Xu, Danqing,et al. Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells[J]. MOLECULES,2015,20(6):11387-11399.
APA Xia, Zhengxiang.,Zhang, Hong.,Xu, Danqing.,Lao, Yuanzhi.,Fu, Wenwei.,...&Xu, Hongxi.(2015).Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells.MOLECULES,20(6),11387-11399.
MLA Xia, Zhengxiang,et al."Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells".MOLECULES 20.6(2015):11387-11399.
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