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题名: Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells
作者: Xia, Zhengxiang1, 2;  Zhang, Hong1, 2;  Xu, Danqing1, 2;  Lao, Yuanzhi1, 2;  Fu, Wenwei1, 2;  Tan, Hongsheng1, 2;  Cao, Peng3;  Yang, Ling4;  Xu, Hongxi1, 2
关键词: Garcinia cowa ;  xanthone ;  cytotoxicity ;  apoptosis ;  cell cycle arrest ;  autophagy
刊名: MOLECULES
发表日期: 2015-06-01
DOI: 10.3390/molecules200611387
卷: 20, 期:6, 页:11387-11399
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
英文摘要: Two new xanthones, cowaxanthones G (1) and H (2), and 23 known analogues were isolated from an acetone extract of the leaves of Garcinia cowa. The isolated compounds were evaluated for cytotoxicity against three cancer cell lines and immortalized HL7702 normal liver cells, whereby compounds 1, 5, 8, and 15-17 exhibited significant cytotoxicity. Cell cycle analysis using flow cytometry showed that 5 induced cell cycle arrest at the S phase in a dose-dependent manner, 1 and 16 at the G2/M phase, and 17 at the G1 phase, while 16 and 17 induced apoptosis. Moreover, autophagy analysis by GFP-LC3 puncta formation and western blotting suggested that 17 induced autophagy. Taken together, our results suggest that these xanthones possess anticancer activities targeting cell cycle, apoptosis, and autophagy signaling pathways.
关键词[WOS]: POLYPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES ;  PRENYLATED XANTHONES ;  MANGOSTANA ;  TWIGS ;  BENZOPHENONE ;  CONSTITUENTS ;  METABOLISM ;  BARK
语种: 英语
WOS记录号: WOS:000357992700115
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146402
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
2.Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China
3.Jiangsu Prov Acad Tradit Chinese Med, Nanjing 210028, Jiangsu, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China

Recommended Citation:
Xia, Zhengxiang,Zhang, Hong,Xu, Danqing,et al. Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells[J]. MOLECULES,2015,20(6):11387-11399.
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