DICP OpenIR
Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells
Xia, Zhengxiang1,2; Zhang, Hong1,2; Xu, Danqing1,2; Lao, Yuanzhi1,2; Fu, Wenwei1,2; Tan, Hongsheng1,2; Cao, Peng3; Yang, Ling4; Xu, Hongxi1,2
KeywordGarcinia Cowa Xanthone Cytotoxicity Apoptosis Cell Cycle Arrest Autophagy
Source PublicationMOLECULES
2015-06-01
DOI10.3390/molecules200611387
Volume20Issue:6Pages:11387-11399
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Organic
WOS Research AreaChemistry
WOS KeywordPOLYPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES ; PRENYLATED XANTHONES ; MANGOSTANA ; TWIGS ; BENZOPHENONE ; CONSTITUENTS ; METABOLISM ; BARK
AbstractTwo new xanthones, cowaxanthones G (1) and H (2), and 23 known analogues were isolated from an acetone extract of the leaves of Garcinia cowa. The isolated compounds were evaluated for cytotoxicity against three cancer cell lines and immortalized HL7702 normal liver cells, whereby compounds 1, 5, 8, and 15-17 exhibited significant cytotoxicity. Cell cycle analysis using flow cytometry showed that 5 induced cell cycle arrest at the S phase in a dose-dependent manner, 1 and 16 at the G2/M phase, and 17 at the G1 phase, while 16 and 17 induced apoptosis. Moreover, autophagy analysis by GFP-LC3 puncta formation and western blotting suggested that 17 induced autophagy. Taken together, our results suggest that these xanthones possess anticancer activities targeting cell cycle, apoptosis, and autophagy signaling pathways.
Language英语
WOS IDWOS:000357992700115
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146402
Collection中国科学院大连化学物理研究所
Affiliation1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
2.Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China
3.Jiangsu Prov Acad Tradit Chinese Med, Nanjing 210028, Jiangsu, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Xia, Zhengxiang,Zhang, Hong,Xu, Danqing,et al. Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells[J]. MOLECULES,2015,20(6):11387-11399.
APA Xia, Zhengxiang.,Zhang, Hong.,Xu, Danqing.,Lao, Yuanzhi.,Fu, Wenwei.,...&Xu, Hongxi.(2015).Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells.MOLECULES,20(6),11387-11399.
MLA Xia, Zhengxiang,et al."Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells".MOLECULES 20.6(2015):11387-11399.
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