DICP OpenIR
Exhaled breath volatile biomarker analysis for thyroid cancer
Guo, Lei; Wang, Changsong; Chi, Chunjie; Wang, Xiaoyang; Liu, Shanshan; Zhao, Wei; Ke, Chaofu; Xu, Guowang; Li, Enyou1
Source PublicationTRANSLATIONAL RESEARCH
2015-08-01
DOI10.1016/j.trsl.2015.01.005
Volume166Issue:2Pages:188-195
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectMedical Laboratory Technology ; Medicine, General & Internal ; Medicine, Research & Experimental
WOS Research AreaMedical Laboratory Technology ; General & Internal Medicine ; Research & Experimental Medicine
WOS KeywordFINE-NEEDLE-ASPIRATION ; LUNG-CANCER ; ORGANIC-COMPOUNDS ; GAMMA-HYDROXYBUTYRATE ; SYSTEMS BIOLOGY ; DIAGNOSIS ; BENIGN ; METABOLISM ; NODULES
AbstractCompared with other types of cancer, thyroid cancer incidence rates have increased rapidly worldwide in the past few decades. In recent years, potential thyroid cancer biomarkers have been studied, but these biomarkers have neither specificity nor good positive predictive value. Exhaled breath analysis is a recently developed convenient and noninvasive method for screening and diagnosing the disease. In this study, potential thyroid cancer biomarkers in volatile organic compounds (VOCs) were detected. Exhaled breath was collected from 64 patients with histologically confirmed cases of thyroid disease (including 39 individuals with papillary thyroid carcinoma and 25 individuals with nodular goiters) and 32 healthy volunteers. Solid-phase microextraction-gas chromatography and mass spectrometry was used to assess the exhaled VOCs of the study participants. The statistical methods of principal component analysis and partial least-squares discriminant analysis were performed to process the final data. The VOCs exhibited significant differences between nodular goiter patients and normal controls, papillary thyroid carcinoma patients and normal controls, and papillary thyroid carcinoma patients and nodular goiter patients; 7, 7, and 3 characteristic metabolites played decisive roles in sample classification, respectively. Breath analysis may provide a new, noninvasive, and directly qualitative method for the clinical diagnosis of thyroid disease.
Language英语
WOS IDWOS:000358821500007
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146433
Collection中国科学院大连化学物理研究所
Affiliation1.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin 150001, Heilongjiang, Peoples R China
2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin 150001, Heilongjiang, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Guo, Lei,Wang, Changsong,Chi, Chunjie,et al. Exhaled breath volatile biomarker analysis for thyroid cancer[J]. TRANSLATIONAL RESEARCH,2015,166(2):188-195.
APA Guo, Lei.,Wang, Changsong.,Chi, Chunjie.,Wang, Xiaoyang.,Liu, Shanshan.,...&Li, Enyou.(2015).Exhaled breath volatile biomarker analysis for thyroid cancer.TRANSLATIONAL RESEARCH,166(2),188-195.
MLA Guo, Lei,et al."Exhaled breath volatile biomarker analysis for thyroid cancer".TRANSLATIONAL RESEARCH 166.2(2015):188-195.
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