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题名: Exhaled breath volatile biomarker analysis for thyroid cancer
作者: Guo, Lei;  Wang, Changsong;  Chi, Chunjie;  Wang, Xiaoyang;  Liu, Shanshan;  Zhao, Wei;  Ke, Chaofu;  Xu, Guowang;  Li, Enyou1
刊名: TRANSLATIONAL RESEARCH
发表日期: 2015-08-01
DOI: 10.1016/j.trsl.2015.01.005
卷: 166, 期:2, 页:188-195
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Medical Laboratory Technology ;  Medicine, General & Internal ;  Medicine, Research & Experimental
研究领域[WOS]: Medical Laboratory Technology ;  General & Internal Medicine ;  Research & Experimental Medicine
英文摘要: Compared with other types of cancer, thyroid cancer incidence rates have increased rapidly worldwide in the past few decades. In recent years, potential thyroid cancer biomarkers have been studied, but these biomarkers have neither specificity nor good positive predictive value. Exhaled breath analysis is a recently developed convenient and noninvasive method for screening and diagnosing the disease. In this study, potential thyroid cancer biomarkers in volatile organic compounds (VOCs) were detected. Exhaled breath was collected from 64 patients with histologically confirmed cases of thyroid disease (including 39 individuals with papillary thyroid carcinoma and 25 individuals with nodular goiters) and 32 healthy volunteers. Solid-phase microextraction-gas chromatography and mass spectrometry was used to assess the exhaled VOCs of the study participants. The statistical methods of principal component analysis and partial least-squares discriminant analysis were performed to process the final data. The VOCs exhibited significant differences between nodular goiter patients and normal controls, papillary thyroid carcinoma patients and normal controls, and papillary thyroid carcinoma patients and nodular goiter patients; 7, 7, and 3 characteristic metabolites played decisive roles in sample classification, respectively. Breath analysis may provide a new, noninvasive, and directly qualitative method for the clinical diagnosis of thyroid disease.
关键词[WOS]: FINE-NEEDLE-ASPIRATION ;  LUNG-CANCER ;  ORGANIC-COMPOUNDS ;  GAMMA-HYDROXYBUTYRATE ;  SYSTEMS BIOLOGY ;  DIAGNOSIS ;  BENIGN ;  METABOLISM ;  NODULES
语种: 英语
WOS记录号: WOS:000358821500007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146433
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin 150001, Heilongjiang, Peoples R China
2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin 150001, Heilongjiang, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China

Recommended Citation:
Guo, Lei,Wang, Changsong,Chi, Chunjie,et al. Exhaled breath volatile biomarker analysis for thyroid cancer[J]. TRANSLATIONAL RESEARCH,2015,166(2):188-195.
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