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题名: Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues
作者: Zhang, Xu1;  Meng, Zhaoxu1;  Ma, Jingyun1;  Shi, Yang1;  Xu, Hui1, 2;  Lykkemark, Simon1, 3;  Qin, Jianhua1
关键词: building block ;  collagen ;  microdevices ;  microtissues ;  self assembly
刊名: SMALL
发表日期: 2015-08-12
DOI: 10.1002/smll.201500556
卷: 11, 期:30, 页:3666-3675
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Multidisciplinary ;  Chemistry, Physical ;  Nanoscience & Nanotechnology ;  Materials Science, Multidisciplinary ;  Physics, Applied ;  Physics, Condensed Matter
研究领域[WOS]: Chemistry ;  Science & Technology - Other Topics ;  Materials Science ;  Physics
英文摘要: Creating artificial tissue-like structures that possess the functionality, specificity, and architecture of native tissues remains a big challenge. A new and straightforward strategy for generating shape-controlled collagen building blocks with a well-defined architecture is presented, which can be used for self-assembly of complex 3D microtissues. Collagen blocks with tunable geometries are controllably produced and released via a membrane-templated microdevice. The formation of functional microtissues by embedding tissue-specific cells into collagen blocks with expression of specific proteins is described. The spontaneous self-assembly of cell-laden collagen blocks into organized tissue constructs with predetermined configurations is demonstrated, which are largely driven by the synergistic effects of cell-cell and cell-matrix interactions. This new strategy would open up new avenues for the study of tissue/organ morphogenesis, and tissue engineering applications.
关键词[WOS]: CELL-LADEN MICROGELS ;  HYDROGELS ;  TISSUES ;  BIOMATERIALS ;  ORGANIZATION ;  MICROFIBERS ;  CONSTRUCTS ;  SCAFFOLDS
语种: 英语
WOS记录号: WOS:000359307700012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146435
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Aarhus Univ, Dept Clin Med, DK-8000 Aarhus C, Denmark

Recommended Citation:
Zhang, Xu,Meng, Zhaoxu,Ma, Jingyun,et al. Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues[J]. SMALL,2015,11(30):3666-3675.
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