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Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues
Zhang, Xu1; Meng, Zhaoxu1; Ma, Jingyun1; Shi, Yang1; Xu, Hui1,2; Lykkemark, Simon1,3; Qin, Jianhua1
关键词Building Block Collagen Microdevices Microtissues Self Assembly
刊名SMALL
2015-08-12
DOI10.1002/smll.201500556
11期:30页:3666-3675
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]CELL-LADEN MICROGELS ; HYDROGELS ; TISSUES ; BIOMATERIALS ; ORGANIZATION ; MICROFIBERS ; CONSTRUCTS ; SCAFFOLDS
英文摘要Creating artificial tissue-like structures that possess the functionality, specificity, and architecture of native tissues remains a big challenge. A new and straightforward strategy for generating shape-controlled collagen building blocks with a well-defined architecture is presented, which can be used for self-assembly of complex 3D microtissues. Collagen blocks with tunable geometries are controllably produced and released via a membrane-templated microdevice. The formation of functional microtissues by embedding tissue-specific cells into collagen blocks with expression of specific proteins is described. The spontaneous self-assembly of cell-laden collagen blocks into organized tissue constructs with predetermined configurations is demonstrated, which are largely driven by the synergistic effects of cell-cell and cell-matrix interactions. This new strategy would open up new avenues for the study of tissue/organ morphogenesis, and tissue engineering applications.
语种英语
WOS记录号WOS:000359307700012
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146435
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Aarhus Univ, Dept Clin Med, DK-8000 Aarhus C, Denmark
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GB/T 7714
Zhang, Xu,Meng, Zhaoxu,Ma, Jingyun,et al. Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues[J]. SMALL,2015,11(30):3666-3675.
APA Zhang, Xu.,Meng, Zhaoxu.,Ma, Jingyun.,Shi, Yang.,Xu, Hui.,...&Qin, Jianhua.(2015).Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues.SMALL,11(30),3666-3675.
MLA Zhang, Xu,et al."Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues".SMALL 11.30(2015):3666-3675.
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