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Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery
Hansen, Jakob S.1,2; Zhao, Xinjie3; Irmler, Martin4; Liu, Xinyu3; Hoene, Miriam5; Scheler, Mika4,6; Li, Yanjie3; Beckers, Johannes4,6,7; de Angelis, Martin Hrabe4,6,7; Haering, Hans-Ulrich; Pedersen, Bente K.1; Lehmann, Rainer; Xu, Guowang3; Plomgaard, Peter1,2; Weigert, Cora5,6,8
关键词Basic Science Exercise Human Metabolomics Microarray Pathophysiology/metabolism
刊名DIABETOLOGIA
2015-08-01
DOI10.1007/s00125-015-3584-x
58期:8页:1845-1854
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]SKELETAL-MUSCLE ; INSULIN-RESISTANCE ; INTENSITY EXERCISE ; FATTY LIVER ; OXIDATION ; HUMANS ; MEN ; ACYLCARNITINES ; MARKERS ; RISK
英文摘要Aims/hypothesis The therapeutic benefit of physical activity to prevent and treat type 2 diabetes is commonly accepted. However, the impact of the disease on the acute metabolic response is less clear. To this end, we investigated the effect of type 2 diabetes on exercise-induced plasma metabolite changes and the muscular transcriptional response using a complementary metabolomics/transcriptomics approach.
语种英语
WOS记录号WOS:000358877300024
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146436
专题中国科学院大连化学物理研究所
作者单位1.Rigshosp, Dept Infect Dis, Ctr Phys Act Res, Ctr Inflammat & Metab, DK-2100 Copenhagen, Denmark
2.Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
4.German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Expt Genet, Neuherberg, Germany
5.Univ Tubingen, Div Pathobiochem & Clin Chem, Dept Internal Med, D-72076 Tubingen, Germany
6.German Ctr Diabet Res DZD, Berlin, Germany
7.Tech Univ Munich, Ctr Life & Food Sci Weihenstephan, Chair Expt Genet, Freising Weihenstephan, Germany
8.Univ Tubingen, Helmholtz Zentrum Munchen, Inst Diabet Res & Metab Dis, Tubingen, Germany
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Hansen, Jakob S.,Zhao, Xinjie,Irmler, Martin,et al. Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery[J]. DIABETOLOGIA,2015,58(8):1845-1854.
APA Hansen, Jakob S..,Zhao, Xinjie.,Irmler, Martin.,Liu, Xinyu.,Hoene, Miriam.,...&Weigert, Cora.(2015).Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery.DIABETOLOGIA,58(8),1845-1854.
MLA Hansen, Jakob S.,et al."Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery".DIABETOLOGIA 58.8(2015):1845-1854.
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