One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging

doi:10.1039/c5ra09948j

DICP OpenIR

	One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging
	Liao, Han 1,2; Wang, Ziyi 1,4; Chen, Song 1,5; Wu, Hao 1,2; Ma, Xiaojun 1; Tan, Mingqian 1,3
Source Publication	RSC ADVANCES
	2015
DOI	10.1039/c5ra09948j
Volume	5 Issue:82 Pages:66575-66581
Indexed By	SCI
Subtype	Article
WOS Headings	Science & Technology ; Physical Sciences
WOS Subject	Chemistry, Multidisciplinary
WOS Research Area	Chemistry
WOS Keyword	QUANTUM DOTS ; CANCER-CELLS ; ENHANCED-FLUORESCENCE ; MAGNETIC-RESONANCE ; FACILE PREPARATION ; DELIVERY ; PHOTOLUMINESCENCE ; NANOPROBES ; GREEN ; PROBE
Abstract	A combination of fluorescence and magnetic resonance imaging (MRI) can provide high-resolution macroscopical anatomical information and high-sensitivity microscopical optical signal simultaneously. In this work, harmless gadolinium(III) doped carbon dots are synthesized in a convenient one-pot hydrothermal approach and used for fluorescence/magnetic resonance multimodal imaging. Unlike typical carbon dots, TEM analysis shows that the carbon dots are particles with irregular shape. Furthermore, Fourier-transform infrared (FTIR) spectra demonstrated structural difference between gadolinium-undoped and doped carbon dots. Nonetheless, the gadolinium-doped carbon dots exhibit strong and stable fluorescence with excitation-dependent emission behavior. Moreover, as an MRI contrast agent, the gadolinium-doped carbon dots represent considerable magnetic resonance properties with a longitudinal relaxation rate of 14.08 mM(-1) s(-1). In addition, cytotoxicity study reveals that the gadolinium-doped carbon dots show very low toxicity to NCI-H446 cells with an IC50 value of 6.28 mg mL(-1). Direct application in cell labeling and in vivo MRI suggests that the gadolinium-doped carbon dots are dual functional fluorescent/MRI probes with excellent biocompatibility.
Language	英语
WOS ID	WOS:000359251600010
Citation statistics	Cited Times:17[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://cas-ir.dicp.ac.cn/handle/321008/146454
Collection	中国科学院大连化学物理研究所
Affiliation	1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Dalian Polytech Univ, Sch Food Sci & Technol, Dalian 116034, Peoples R China 4.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China 5.Dalian Med Univ, Dalian 116044, Peoples R China
Recommended Citation GB/T 7714	Liao, Han,Wang, Ziyi,Chen, Song,et al. One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging[J]. RSC ADVANCES,2015,5(82):66575-66581.
APA	Liao, Han,Wang, Ziyi,Chen, Song,Wu, Hao,Ma, Xiaojun,&Tan, Mingqian.(2015).One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging.RSC ADVANCES,5(82),66575-66581.
MLA	Liao, Han,et al."One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging".RSC ADVANCES 5.82(2015):66575-66581.

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