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题名: One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging
作者: Liao, Han1, 2;  Wang, Ziyi1, 4;  Chen, Song1, 5;  Wu, Hao1, 2;  Ma, Xiaojun1;  Tan, Mingqian1, 3
刊名: RSC ADVANCES
发表日期: 2015
DOI: 10.1039/c5ra09948j
卷: 5, 期:82, 页:66575-66581
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: A combination of fluorescence and magnetic resonance imaging (MRI) can provide high-resolution macroscopical anatomical information and high-sensitivity microscopical optical signal simultaneously. In this work, harmless gadolinium(III) doped carbon dots are synthesized in a convenient one-pot hydrothermal approach and used for fluorescence/magnetic resonance multimodal imaging. Unlike typical carbon dots, TEM analysis shows that the carbon dots are particles with irregular shape. Furthermore, Fourier-transform infrared (FTIR) spectra demonstrated structural difference between gadolinium-undoped and doped carbon dots. Nonetheless, the gadolinium-doped carbon dots exhibit strong and stable fluorescence with excitation-dependent emission behavior. Moreover, as an MRI contrast agent, the gadolinium-doped carbon dots represent considerable magnetic resonance properties with a longitudinal relaxation rate of 14.08 mM(-1) s(-1). In addition, cytotoxicity study reveals that the gadolinium-doped carbon dots show very low toxicity to NCI-H446 cells with an IC50 value of 6.28 mg mL(-1). Direct application in cell labeling and in vivo MRI suggests that the gadolinium-doped carbon dots are dual functional fluorescent/MRI probes with excellent biocompatibility.
关键词[WOS]: QUANTUM DOTS ;  CANCER-CELLS ;  ENHANCED-FLUORESCENCE ;  MAGNETIC-RESONANCE ;  FACILE PREPARATION ;  DELIVERY ;  PHOTOLUMINESCENCE ;  NANOPROBES ;  GREEN ;  PROBE
语种: 英语
WOS记录号: WOS:000359251600010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146454
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Polytech Univ, Sch Food Sci & Technol, Dalian 116034, Peoples R China
4.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China
5.Dalian Med Univ, Dalian 116044, Peoples R China

Recommended Citation:
Liao, Han,Wang, Ziyi,Chen, Song,et al. One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging[J]. RSC ADVANCES,2015,5(82):66575-66581.
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