DICP OpenIR
One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging
Liao, Han1,2; Wang, Ziyi1,4; Chen, Song1,5; Wu, Hao1,2; Ma, Xiaojun1; Tan, Mingqian1,3
Source PublicationRSC ADVANCES
2015
DOI10.1039/c5ra09948j
Volume5Issue:82Pages:66575-66581
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordQUANTUM DOTS ; CANCER-CELLS ; ENHANCED-FLUORESCENCE ; MAGNETIC-RESONANCE ; FACILE PREPARATION ; DELIVERY ; PHOTOLUMINESCENCE ; NANOPROBES ; GREEN ; PROBE
AbstractA combination of fluorescence and magnetic resonance imaging (MRI) can provide high-resolution macroscopical anatomical information and high-sensitivity microscopical optical signal simultaneously. In this work, harmless gadolinium(III) doped carbon dots are synthesized in a convenient one-pot hydrothermal approach and used for fluorescence/magnetic resonance multimodal imaging. Unlike typical carbon dots, TEM analysis shows that the carbon dots are particles with irregular shape. Furthermore, Fourier-transform infrared (FTIR) spectra demonstrated structural difference between gadolinium-undoped and doped carbon dots. Nonetheless, the gadolinium-doped carbon dots exhibit strong and stable fluorescence with excitation-dependent emission behavior. Moreover, as an MRI contrast agent, the gadolinium-doped carbon dots represent considerable magnetic resonance properties with a longitudinal relaxation rate of 14.08 mM(-1) s(-1). In addition, cytotoxicity study reveals that the gadolinium-doped carbon dots show very low toxicity to NCI-H446 cells with an IC50 value of 6.28 mg mL(-1). Direct application in cell labeling and in vivo MRI suggests that the gadolinium-doped carbon dots are dual functional fluorescent/MRI probes with excellent biocompatibility.
Language英语
WOS IDWOS:000359251600010
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146454
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Polytech Univ, Sch Food Sci & Technol, Dalian 116034, Peoples R China
4.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China
5.Dalian Med Univ, Dalian 116044, Peoples R China
Recommended Citation
GB/T 7714
Liao, Han,Wang, Ziyi,Chen, Song,et al. One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging[J]. RSC ADVANCES,2015,5(82):66575-66581.
APA Liao, Han,Wang, Ziyi,Chen, Song,Wu, Hao,Ma, Xiaojun,&Tan, Mingqian.(2015).One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging.RSC ADVANCES,5(82),66575-66581.
MLA Liao, Han,et al."One-pot synthesis of gadolinium(III) doped carbon dots for fluorescence/magnetic resonance bimodal imaging".RSC ADVANCES 5.82(2015):66575-66581.
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