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题名: Facile synthesis of Fe3O4@polyethyleneimine modified with 4-formylphenylboronic acid for the highly selective extraction of major catecholamines from human urine
作者: Qin, Qian1;  Li, Hua1;  Shi, Xianzhe1;  Xu, Guowang1
关键词: Boronate ligands ;  Catecholamines ;  Liquid chromatography with mass spectrometry ;  Magnetic nanoparticles ;  Polyethyleneimine
刊名: JOURNAL OF SEPARATION SCIENCE
发表日期: 2015-08-01
DOI: 10.1002/jssc.201500377
卷: 38, 期:16, 页:2857-2864
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: The levels of catecholamines, especially dopamine, epinephrine and norepinephrine in urine and plasma have been used to assist the diagnosis and treatment of psychosis. Due to their low endogenous concentrations, the determination of the three major catecholamines is very difficult. Boronate adsorbents are often employed to extract these cis-diol compounds from complex matrices. In this work, a novel type of magnetic nanoparticles modified with 4-formylphenylboronic named Fe3O4@PEI-FPBA was synthesized by a facile two-step approach. The abundant amino groups of polyethyleneimine provided the rich binding sites for boronate ligands. Herein, the adsorption capacity of Fe3O4@PEI-FPBA is greatly improved with a value of 3.45 mg/g towards epinephrine, which is much larger than that of analogous material without polyethyleneimine. The magnetic nanoparticles also exhibited high magnetization (72.25 emu/g) and specific selectivity towards the catecholamines. Finally, a liquid chromatography tandem mass spectrometry method based on Fe3O4@PEI-FPBA nanoparticles was successfully used to determine the three catecholamines from human urine samples. The linearity, limit of quantitation, recovery and precision of the method were satisfactory. Based on the method, it is found that the levels of dopamine, epinephrine and norepinephrine in depressive patients are higher than those in healthy controls.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  DIOL-CONTAINING BIOMOLECULES ;  FUNCTIONALIZED MAGNETIC NANOPARTICLES ;  CIS-DIOL ;  ELECTROCHEMICAL DETECTION ;  PLASMA-CATECHOLAMINES ;  MONOLITHIC CAPILLARY ;  TRACE GLYCOPROTEINS ;  AFFINITY CAPTURE ;  BORONATE AVIDITY
语种: 英语
WOS记录号: WOS:000360092700014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146487
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Qin, Qian,Li, Hua,Shi, Xianzhe,et al. Facile synthesis of Fe3O4@polyethyleneimine modified with 4-formylphenylboronic acid for the highly selective extraction of major catecholamines from human urine[J]. JOURNAL OF SEPARATION SCIENCE,2015,38(16):2857-2864.
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