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Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process
Ji, Yue1; Shi, Lei1,2; Chen, Mu-Wang1; Feng, Guang-Shou1; Zhou, Yong-Gui1
刊名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2015-08-26
DOI10.1021/jacs.5b06659
137期:33页:10496-10499
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]DYNAMIC KINETIC RESOLUTION ; IRIDIUM-CATALYZED HYDROGENATION ; TANDEM BIOCATALYTIC OXIDATION ; ASYMMETRIC ALLYLIC ALKYLATION ; SUBSTITUTED CARBOXYLIC-ACIDS ; MICROBIAL DERACEMIZATION ; ENANTIOSELECTIVE HYDROGENATION ; ONE-POT ; ALCOHOLS ; DERACEMISATION
英文摘要A concise deracemization of racemic secondary and tertiary amines with a tetrahydroisoquinoline core has been successfully realized by orchestrating a redox process consisted of N-bromosuccinimide oxidation and iridum-catalyzed asymmetric hydrogenation. This compatible redox combination enables one-pot, single-operation deracemization to generate chiral 1-substituted 1,2,3,4-tetrahydroisoquinolines with up to 98% ee in 93% yield, offering a simple and scalable synthetic technique for chiral amines directly from racemic starting materials.
语种英语
WOS记录号WOS:000360321100014
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146497
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China
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GB/T 7714
Ji, Yue,Shi, Lei,Chen, Mu-Wang,et al. Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2015,137(33):10496-10499.
APA Ji, Yue,Shi, Lei,Chen, Mu-Wang,Feng, Guang-Shou,&Zhou, Yong-Gui.(2015).Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,137(33),10496-10499.
MLA Ji, Yue,et al."Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137.33(2015):10496-10499.
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