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题名: Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process
作者: Ji, Yue1;  Shi, Lei1, 2;  Chen, Mu-Wang1;  Feng, Guang-Shou1;  Zhou, Yong-Gui1
刊名: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
发表日期: 2015-08-26
DOI: 10.1021/jacs.5b06659
卷: 137, 期:33, 页:10496-10499
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: A concise deracemization of racemic secondary and tertiary amines with a tetrahydroisoquinoline core has been successfully realized by orchestrating a redox process consisted of N-bromosuccinimide oxidation and iridum-catalyzed asymmetric hydrogenation. This compatible redox combination enables one-pot, single-operation deracemization to generate chiral 1-substituted 1,2,3,4-tetrahydroisoquinolines with up to 98% ee in 93% yield, offering a simple and scalable synthetic technique for chiral amines directly from racemic starting materials.
关键词[WOS]: DYNAMIC KINETIC RESOLUTION ;  IRIDIUM-CATALYZED HYDROGENATION ;  TANDEM BIOCATALYTIC OXIDATION ;  ASYMMETRIC ALLYLIC ALKYLATION ;  SUBSTITUTED CARBOXYLIC-ACIDS ;  MICROBIAL DERACEMIZATION ;  ENANTIOSELECTIVE HYDROGENATION ;  ONE-POT ;  ALCOHOLS ;  DERACEMISATION
语种: 英语
WOS记录号: WOS:000360321100014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146497
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

Recommended Citation:
Ji, Yue,Shi, Lei,Chen, Mu-Wang,et al. Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2015,137(33):10496-10499.
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